Ayaz Ridvan Aziz, Yozlu Deniz, Arisan Elif Damla
Institute of Biotechnology, Gebze Technical University, Gebze, Kocaeli, Türkiye.
Institute of Neurological Sciences, Department of Neurogenetics, Istanbul University-Cerrahpaşa, Istanbul, Türkiye.
MicroPubl Biol. 2025 Jun 5;2025. doi: 10.17912/micropub.biology.001618. eCollection 2025.
is emerging as a valuable model for investigating chemosensory responses to disease-associated molecular cues recently. In this study, we examined the chemotaxis behavior of toward the conditioned media from cancerous MIA PaCa-2 and PANC-1 cells and non-cancerous PNT1A cells. Untrained wild-type worms exhibited orientation to PNT1A media compared to the controls. Most importantly, training with cancer-conditioned media led to altered chemotaxis behavior, indicating olfactory learning. These findings support the use of as a sensitive and adaptable system for detecting cancer-associated metabolites and demonstrate its potential role in non-invasive cancer screening applications and training-based models.
最近，它正在成为一种用于研究对疾病相关分子线索的化学感应反应的有价值模型。在本研究中，我们检测了其对来自癌性MIA PaCa-2和PANC-1细胞以及非癌性PNT1A细胞的条件培养基的趋化行为。与对照相比，未经训练的野生型线虫表现出对PNT1A培养基的定向。最重要的是，用癌症条件培养基进行训练导致趋化行为改变，表明存在嗅觉学习。这些发现支持将其用作检测癌症相关代谢物的灵敏且适应性强的系统，并证明了其在非侵入性癌症筛查应用和基于训练的模型中的潜在作用。
