Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Am J Clin Nutr. 2010 May;91(5):1268-72. doi: 10.3945/ajcn.2009.28837. Epub 2010 Mar 24.
Many women use multivitamins in the belief that these supplements will prevent chronic diseases such as cancer and cardiovascular disease. However, whether the use of multivitamins affects the risk of breast cancer is unclear.
We prospectively examined the association between multivitamin use and the incidence of invasive breast cancer in the Swedish Mammography Cohort.
In 1997, 35,329 cancer-free women completed a self-administered questionnaire that solicited information on multivitamin use as well as other breast cancer risk factors. Relative risks (RRs) and 95% CIs were calculated by using Cox proportional hazard models and adjusted for breast cancer risk factors.
During a mean follow-up of 9.5 y, 974 women were diagnosed with incident breast cancer. Multivitamin use was associated with a statistically significant increased risk of breast cancer. The multivariable RR of women who reported the use of multivitamins was 1.19 (95% CI: 1.04, 1.37). The association did not differ significantly by hormone receptor status of the breast tumor.
These results suggest that multivitamin use is associated with an increased risk of breast cancer. This observed association is of concern and merits further investigation.
许多女性服用多种维生素，相信这些补充剂可以预防癌症和心血管疾病等慢性病。然而，服用多种维生素是否会影响乳腺癌的风险尚不清楚。
我们前瞻性地研究了瑞典乳腺队列中多种维生素使用与浸润性乳腺癌发病之间的关系。
1997 年，35329 名无癌症的女性完成了一份自我管理的问卷，其中包括多种维生素使用情况以及其他乳腺癌危险因素的信息。使用 Cox 比例风险模型计算相对风险（RR）和 95%置信区间（CI），并根据乳腺癌危险因素进行调整。
在平均 9.5 年的随访期间，974 名女性被诊断出患有乳腺癌。多种维生素的使用与乳腺癌风险呈统计学显著增加相关。报告使用多种维生素的女性的多变量 RR 为 1.19（95%CI：1.04，1.37）。该关联与乳腺肿瘤的激素受体状态无显著差异。
这些结果表明，多种维生素的使用与乳腺癌风险增加有关。这种观察到的关联令人担忧，值得进一步研究。
