氧化震颤素对大鼠膈神经乙酰胆碱释放的增强作用。
Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve.
作者信息
Das M, Ganguly D K, Vedasiromoni J R
出版信息
Br J Pharmacol. 1978 Feb;62(2):195-8. doi: 10.1111/j.1476-5381.1978.tb08445.x.
Abstract
Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation. 2 The paralytic effect of oxotremorine was absent when the diaphragm was stimulated directly in the presence of hemicholinium-3 (0.42 mM), at a time when twitch responses to indirect stimulation ceased completely. 3 Oxotremorine, at two different pharmacologically active doses, strikingly increased the resting as well as electrically evoked release of acetylcholine into the bathing fluid from the phrenic nerve-diaphragm preparation. 4 This presynaptic effect of oxotremorine may explain its pharmacological effects at the cholinergic synapses studied so far.
摘要
氧化震颤素（10.5微米）对体外大鼠膈肌对直接和间接刺激的抽搐反应产生麻痹作用。2当在半胱氨酸-3（0.42毫摩尔）存在的情况下直接刺激膈肌时，氧化震颤素的麻痹作用消失，此时对间接刺激的抽搐反应完全停止。3氧化震颤素在两种不同的药理活性剂量下，显著增加了从膈神经-膈肌标本中乙酰胆碱向浴液中的静息释放以及电诱发释放。4氧化震颤素的这种突触前效应可能解释了其迄今为止在所研究的胆碱能突触处的药理作用。
相似文献
1
Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve.氧化震颤素对大鼠膈神经乙酰胆碱释放的增强作用。
Br J Pharmacol. 1978 Feb;62(2):195-8. doi: 10.1111/j.1476-5381.1978.tb08445.x.
2
Nicotinic actions of oxotremorine on murine skeletal muscle. Evidence against muscarinic modulation of acetylcholine release.氧化震颤素对小鼠骨骼肌的烟碱样作用。反对毒蕈碱调节乙酰胆碱释放的证据。
Brain Res. 1990 Nov 26;534(1-2):142-8. doi: 10.1016/0006-8993(90)90124-t.
3
Comparative effects of atropine and oxotremorine on neuromuscular transmission at the rat hemidiaphragm preparation.阿托品与氧化震颤素对大鼠半膈制备物神经肌肉传递的比较作用。
Arch Int Pharmacodyn Ther. 1987 Jul;288(1):120-35.
4
Rat isolated phrenic nerve-diaphragm preparation for pharmacological study of muscle spindle afferent activity: effect of oxotremorine.用于肌肉纺锤体传入活动药理学研究的大鼠膈神经-膈肌标本：氧化震颤素的作用
Br J Pharmacol. 1978 Sep;64(1):47-52. doi: 10.1111/j.1476-5381.1978.tb08639.x.
5
The effects of atropine and oxotremorine on acetylcholine release in rat phrenic nerve-diaphragm preparations.阿托品和氧化震颤素对大鼠膈神经-膈肌标本中乙酰胆碱释放的影响。
Br J Pharmacol. 1981 Jun;73(2):481-3. doi: 10.1111/j.1476-5381.1981.tb10446.x.
6
Cholinergic agonist and antagonist interactions on motor nerve endings of the rat--evidence for the involvement of presynaptic receptors in the regulation of acetylcholine release.胆碱能激动剂和拮抗剂对大鼠运动神经末梢的相互作用——突触前受体参与乙酰胆碱释放调节的证据
Gen Pharmacol. 1987;18(1):75-81. doi: 10.1016/0306-3623(87)90173-x.
7
On the site of action of hemicholinium-3 at the rat phrenic nerve-diaphragm preparation with special reference to its multiple presynaptic actions.关于半胱氨酸-3在大鼠膈神经-膈肌标本上的作用部位，特别提及它的多种突触前作用。
Neuropharmacology. 1970 Jul;9(4):359-67. doi: 10.1016/0028-3908(70)90033-x.
8
Atropine sulphate enhances neuromuscular transmission in the rat.硫酸阿托品可增强大鼠的神经肌肉传递。
Acta Anaesthesiol Scand. 1987 Oct;31(7):587-92. doi: 10.1111/j.1399-6576.1987.tb02626.x.
9
Effects of desipramine and imipramine on the nerve, muscle and synaptic transmission of rat diaphragms.去甲丙咪嗪和丙咪嗪对大鼠膈肌神经、肌肉及突触传递的影响。
Neuropharmacology. 1972 Nov;11(6):777-88. doi: 10.1016/0028-3908(72)90035-4.
10
Muscarine receptors on the rat phrenic nerve, evidence for positive and negative muscarinic feedback mechanisms.大鼠膈神经上的毒蕈碱受体，毒蕈碱正负反馈机制的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jun;335(6):605-12. doi: 10.1007/BF00166975.
引用本文的文献
1
Oxotremorine does not enhance acetylcholine release from rat diaphragm preparations.氧化震颤素不会增强大鼠膈肌标本中乙酰胆碱的释放。
Br J Pharmacol. 1980 Sep;70(1):8-10. doi: 10.1111/j.1476-5381.1980.tb10897.x.
2
The effects of atropine and oxotremorine on acetylcholine release in rat phrenic nerve-diaphragm preparations.阿托品和氧化震颤素对大鼠膈神经-膈肌标本中乙酰胆碱释放的影响。
Br J Pharmacol. 1981 Jun;73(2):481-3. doi: 10.1111/j.1476-5381.1981.tb10446.x.
3
Release of acetylcholine at the motor endplate of the rat - evidence against a muscarinic acetylcholine autoreceptor.大鼠运动终板乙酰胆碱的释放——反对毒蕈碱型乙酰胆碱自身受体的证据
Br J Pharmacol. 1983 Nov;80(3):471-6. doi: 10.1111/j.1476-5381.1983.tb10717.x.
4
Anti-tremor action of C10Dichol, a peripheral acetylcholine synthesis inhibitor.外周乙酰胆碱合成抑制剂C10二氯醇的抗震颤作用
Br J Pharmacol. 1980;71(1):349-53. doi: 10.1111/j.1476-5381.1980.tb10946.x.
5
Modulation of stimulation-evoked release of newly formed acetylcholine from mouse hemidiaphragm preparation.小鼠半膈肌标本中刺激诱发的新合成乙酰胆碱释放的调节
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jul;336(1):11-5. doi: 10.1007/BF00177744.
6
Phenthonium, a quaternary derivative of (-)-hyoscyamine, enhances the spontaneous release of acetylcholine at rat motor nerve terminals.苯托铵，（-）-莨菪碱的季铵衍生物，可增强大鼠运动神经末梢乙酰胆碱的自发释放。
Br J Pharmacol. 1990 Jul;100(3):441-6. doi: 10.1111/j.1476-5381.1990.tb15825.x.
7
Rat isolated phrenic nerve-diaphragm preparation for pharmacological study of muscle spindle afferent activity: effect of oxotremorine.用于肌肉纺锤体传入活动药理学研究的大鼠膈神经-膈肌标本：氧化震颤素的作用
Br J Pharmacol. 1978 Sep;64(1):47-52. doi: 10.1111/j.1476-5381.1978.tb08639.x.
本文引用的文献
1
EFFECTS OF TRIETHYLCHOLINE ON THE OUTPUT OF ACETYLCHOLINE FROM THE ISOLATED DIAPHRAGM OF THE RAT.三乙胆碱对大鼠离体膈肌乙酰胆碱释放量的影响
Br J Pharmacol Chemother. 1965 Feb;24(1):110-8. doi: 10.1111/j.1476-5381.1965.tb02084.x.
2
EFFECT OF 'TREMORINE' AND SOME ANTI-PARKINSON'S DISEASE DRUGS ON ACETYLCHOLINE IN THE RAT'S BRAIN.“震颤素”及某些抗帕金森病药物对大鼠脑内乙酰胆碱的影响
Nature. 1963 Nov 30;200:895. doi: 10.1038/200895a0.
3
TREMORINE AND ATROPINE EFFECTS ON BRAIN ACETYLCHOLINE.震颤素与阿托品对脑乙酰胆碱的作用
Life Sci (1962). 1963 Oct;10:731-6. doi: 10.1016/0024-3205(63)90077-8.
4
Neuromuscular pharmacology of oxotremorine.
Eur J Pharmacol. 1970 Jul 1;11(1):84-9. doi: 10.1016/0014-2999(70)90257-8.
5
Effect of oxotremorine on acetylcholine content of brain & peripheral tissues in rats.
Indian J Exp Biol. 1969 Jul;7(3):176-7.
6
Antagonism of centrally mediated oxotremorine effects by a peripherally acting drug.
Eur J Pharmacol. 1971;15(3):310-7. doi: 10.1016/0014-2999(71)90097-5.
7
Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine.通过胆碱酯酶抑制和氧化震颤素抑制大脑皮质切片中乙酰胆碱的释放。
Nat New Biol. 1973 Jan 24;241(108):121-2. doi: 10.1038/newbio241121a0.
8
Effect of oxotremorine on the response of antidromically activated Renshaw cells in decerebrate cats.
Exp Brain Res. 1976 May 10;25(1):35-43. doi: 10.1007/BF00237324.
9
Cycrimine on rat diaphragm.环喷托酯对大鼠膈肌的作用。
Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9.
10
Antioxotremorine action of propranolol.普萘洛尔的抗震颤素作用。
Br J Pharmacol. 1976 Jan;56(1):21-4. doi: 10.1111/j.1476-5381.1976.tb06953.x.
Zotero 插件