氧化震颤素对大鼠膈神经乙酰胆碱释放的增强作用。
Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve.
作者信息
Das M, Ganguly D K, Vedasiromoni J R
出版信息
Br J Pharmacol. 1978 Feb;62(2):195-8. doi: 10.1111/j.1476-5381.1978.tb08445.x.
Abstract
Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation. 2 The paralytic effect of oxotremorine was absent when the diaphragm was stimulated directly in the presence of hemicholinium-3 (0.42 mM), at a time when twitch responses to indirect stimulation ceased completely. 3 Oxotremorine, at two different pharmacologically active doses, strikingly increased the resting as well as electrically evoked release of acetylcholine into the bathing fluid from the phrenic nerve-diaphragm preparation. 4 This presynaptic effect of oxotremorine may explain its pharmacological effects at the cholinergic synapses studied so far.
摘要
氧化震颤素（10.5微米）对体外大鼠膈肌对直接和间接刺激的抽搐反应产生麻痹作用。2当在半胱氨酸-3（0.42毫摩尔）存在的情况下直接刺激膈肌时，氧化震颤素的麻痹作用消失，此时对间接刺激的抽搐反应完全停止。3氧化震颤素在两种不同的药理活性剂量下，显著增加了从膈神经-膈肌标本中乙酰胆碱向浴液中的静息释放以及电诱发释放。4氧化震颤素的这种突触前效应可能解释了其迄今为止在所研究的胆碱能突触处的药理作用。
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