阿托品和氧化震颤素对大鼠膈神经-膈肌标本中乙酰胆碱释放的影响。
The effects of atropine and oxotremorine on acetylcholine release in rat phrenic nerve-diaphragm preparations.
作者信息
Abbs E T, Joseph D N
出版信息
Br J Pharmacol. 1981 Jun;73(2):481-3. doi: 10.1111/j.1476-5381.1981.tb10446.x.
Abstract
1 Atropine (10(-5) M) enhanced the release of [3H]-acetylcholine from rat isolated hemidiaphragms, previously incubated with [3H-methyl]-choline, stimulated via their phrenic nerves. 2 Oxotremorine (10(-5) M) did not affect the stimulated release of [3H]-acetylcholine but antagonized the facilitatory effects of atropine (10(-5) M). 3 It is suggested that there are presynaptic inhibitory muscarinic receptors that modulate the release of acetylcholine in the phrenic nerves of the rat.
摘要
- 阿托品（10⁻⁵ M）增强了[³H] - 乙酰胆碱从预先用[³H - 甲基] - 胆碱孵育的大鼠离体半膈肌的释放，通过膈神经刺激半膈肌。2. 氧化震颤素（10⁻⁵ M）不影响[³H] - 乙酰胆碱的刺激释放，但拮抗阿托品（10⁻⁵ M）的促进作用。3. 提示存在突触前抑制性毒蕈碱受体，其调节大鼠膈神经中乙酰胆碱的释放。
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