Mucosal and Vaccine Research Program Colorado, University of Colorado Denver, RC-2, Box B-168, 12700 E. 19th Ave., Aurora, CO 80045, USA.
J Clin Invest. 2010 Apr;120(4):1039-42. doi: 10.1172/JCI42695. Epub 2010 Mar 24.
Antibody-mediated defense against pathogens typically requires complex interactions between antibodies and other constituents of the humoral and cellular immune systems. However, recent evidence indicates that some antibodies alone can inhibit pathogen function in the absence of complement, phagocytes, or NK cells. In this issue of the JCI, McClelland et al. have begun to elucidate the molecular bases by which antibodies alone can impact pathogen growth and metabolism. They show that mAbs specific for the polysaccharide capsule of the human pathogenic fungus Cryptococcus neoformans elicit diverse effects on fungal gene expression, lipid biosynthesis, susceptibility to amphotericin B, cellular metabolism, and protein phosphorylation. These data suggest that pathogens have the capacity to generate broad metabolic responses as a result of surface binding by pathogen-specific antibodies, effects that may hold therapeutic promise.
抗体介导的对病原体的防御通常需要抗体和体液及细胞免疫系统的其他成分之间的复杂相互作用。然而，最近的证据表明，一些抗体本身可以在没有补体、吞噬细胞或自然杀伤细胞的情况下抑制病原体的功能。在本期《临床检查杂志》中，McClelland 等人开始阐明抗体本身可以影响病原体生长和代谢的分子基础。他们表明，针对人类致病真菌新型隐球菌多糖荚膜的 mAb 可引起真菌基因表达、脂质生物合成、两性霉素 B 敏感性、细胞代谢和蛋白质磷酸化的不同变化。这些数据表明，病原体具有由于病原体特异性抗体的表面结合而产生广泛代谢反应的能力，这些作用可能具有治疗前景。
