源自单个B细胞的新型隐球菌保护性和非保护性单克隆抗体。
Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell.
作者信息
Mukherjee J, Nussbaum G, Scharff M D, Casadevall A
机构信息
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461.
出版信息
J Exp Med. 1995 Jan 1;181(1):405-9. doi: 10.1084/jem.181.1.405.
Abstract
Two immunoglobulin M monoclonal antibodies (mAbs) derived from the same B cell recognize different epitopes on the capsular polysaccharide of the pathogenic yeast, Cryptococcus neoformans. Their respective epitopes are located in spatially distinct regions of the capsule. Passive administration of one mAb prolonged survival whereas the other mAb did not. The results indicate that specificity is an important determinant of antibody efficacy against C. neoformans and that somatic mutations occurring during the antibody response can affect the protective efficacy of antibodies to C. neoformans.
摘要
源自同一B细胞的两种免疫球蛋白M单克隆抗体（mAb）识别致病性酵母新型隐球菌荚膜多糖上的不同表位。它们各自的表位位于荚膜的空间不同区域。被动给予一种mAb可延长生存期，而另一种mAb则不能。结果表明，特异性是抗体抗新型隐球菌效力的重要决定因素，并且抗体应答过程中发生的体细胞突变可影响抗体对新型隐球菌的保护效力。
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