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新型隐球菌菌株中可引发保护性抗体的多糖表位的流行情况。

Prevalence in Cryptococcus neoformans strains of a polysaccharide epitope which can elicit protective antibodies.

作者信息

Cleare W, Mukherjee S, Spitzer E D, Casadevall A

机构信息

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

出版信息

Clin Diagn Lab Immunol. 1994 Nov;1(6):737-40. doi: 10.1128/cdli.1.6.737-740.1994.

DOI:10.1128/cdli.1.6.737-740.1994
PMID:8556529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368405/
Abstract

Monoclonal antibody (MAb) 2H1 binds to an epitope in the capsule of Cryptococcus neoformans that can elicit protective antibodies. The binding of MAb 2H1 to C. neoformans strains was studied by agglutination, immunofluorescence, and phagocytosis assays. The MAb 2H1 epitope was present in all 21 isolates studied, including those recovered from patients with recurrent infections.

摘要

单克隆抗体（MAb）2H1与新型隐球菌荚膜中的一个表位结合，该表位可引发保护性抗体。通过凝集试验、免疫荧光试验和吞噬作用试验研究了MAb 2H1与新型隐球菌菌株的结合情况。在所研究的全部21株分离菌株中均存在MAb 2H1表位，包括从复发性感染患者体内分离出的菌株。

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本文引用的文献

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Effects of strain variation, serotype, and structural modification on kinetics for activation and binding of C3 to Cryptococcus neoformans.菌株变异、血清型及结构修饰对C3激活及与新型隐球菌结合动力学的影响。
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