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[射频消融作为耳鼻喉肿瘤姑息治疗选择的体内和体外测试]

[Radiofrequency ablation as a palliative therapy option in ENT tumors: in vivo and in vitro testing].

作者信息

Bucher S, Hornung J, Bonkowsky V, Iro H, Zenk J

机构信息

Hals-Nasen-Ohren-Klinik, Kopf- und Halschirurgie, Universitätsklinikum Erlangen, Waldstrasse 1, 91054, Erlangen, Deutschland.

出版信息

HNO. 2010 Apr;58(4):358-63. doi: 10.1007/s00106-009-2067-0.

DOI:10.1007/s00106-009-2067-0
PMID:20336271
Abstract

BACKGROUND

High frequency thermotherapy (HFTT) is an established palliative therapy for hepatic malignancies. An in vivo and in vitro trial examined the preconditions for the application of HFTT with liquid-cooled wet electrodes for minimally invasive palliation of head and neck tumors.

MATERIAL AND METHOD

HFTT was applied with needle electrodes, cooled with isotonic saline solution, and a high-frequency generator (Elektrotom HiTT 106, Berchtold, Tuttlingen) to porcine tongue and narcotized, juvenile domestic pigs to the tongue and neck, and monitored in realtime by B-mode ultrasound.

RESULTS

The direction of spread of the hyperthermic zone is well observed using ultrasound. Determining the direction of spread is not possible with cooled-tip electrode needles. Severe complications were not observed during the application.

CONCLUSION

RFA with liquid-cooled needle applicators is not safely applicable for the therapy of head and neck tumors.

摘要

背景

高频热疗(HFTT)是一种成熟的肝癌姑息治疗方法。一项体内和体外试验研究了使用液冷湿电极进行高频热疗以对头颈部肿瘤进行微创姑息治疗的应用前提条件。

材料与方法

使用针电极进行高频热疗,针电极用等渗盐溶液冷却,并使用高频发生器(Elektrotom HiTT 106,Berchtold,图特林根)作用于猪舌以及麻醉的幼年家猪的舌部和颈部,并通过B型超声进行实时监测。

结果

使用超声可以很好地观察到热疗区的扩散方向。对于冷却尖端电极针,无法确定扩散方向。在应用过程中未观察到严重并发症。

结论

使用液冷针式施药器进行射频消融术对头颈部肿瘤治疗并不安全适用。

相似文献

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[Radiofrequency ablation as a palliative therapy option in ENT tumors: in vivo and in vitro testing].[射频消融作为耳鼻喉肿瘤姑息治疗选择的体内和体外测试]
HNO. 2010 Apr;58(4):358-63. doi: 10.1007/s00106-009-2067-0.
2
Radiofrequency induced thermotherapy: an alternative palliative treatment modality in head and neck cancer.射频诱导热疗:头颈部癌的一种替代性姑息治疗方式。
Eur Arch Otorhinolaryngol. 2006 Jun;263(6):532-6. doi: 10.1007/s00405-005-0006-6. Epub 2006 Mar 25.
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Korean J Radiol. 2006 Apr-Jun;7(2):97-105. doi: 10.3348/kjr.2006.7.2.97.
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Korean J Radiol. 2004 Oct-Dec;5(4):250-7. doi: 10.3348/kjr.2004.5.4.250.

本文引用的文献

1
CT-guided radiofrequency ablation in the palliative treatment of recurrent advanced head and neck malignancies.CT引导下射频消融术在复发性晚期头颈部恶性肿瘤姑息治疗中的应用
J Vasc Interv Radiol. 2008 May;19(5):725-35. doi: 10.1016/j.jvir.2007.12.439. Epub 2008 Mar 17.
2
Complications of percutaneous radiofrequency thermal ablation of primary and secondary lesions of the liver.肝脏原发性和继发性病变经皮射频热消融的并发症
Anticancer Res. 2007 Jul-Aug;27(4C):2911-6.
3
The safety of radiofrequency thermal ablation in the treatment of liver malignancies.
射频热消融治疗肝脏恶性肿瘤的安全性。
Eur J Surg Oncol. 2008 Jun;34(6):668-72. doi: 10.1016/j.ejso.2007.05.003. Epub 2007 Jul 27.
4
Ultrasound-guided laser-induced thermal therapy of malignant cervical adenopathy.超声引导下激光诱导热疗治疗恶性颈部淋巴结病
Laryngoscope. 2006 Aug;116(8):1507-11. doi: 10.1097/01.mlg.0000230403.13826.69.
5
Radiofrequency ablation and percutaneous ethanol injection treatment for recurrent local and distant well-differentiated thyroid carcinoma.射频消融与经皮乙醇注射治疗复发性局部及远处高分化甲状腺癌。
Ann Surg. 2006 Aug;244(2):296-304. doi: 10.1097/01.sla.0000217685.85467.2d.
6
Radiofrequency induced thermotherapy: an alternative palliative treatment modality in head and neck cancer.射频诱导热疗:头颈部癌的一种替代性姑息治疗方式。
Eur Arch Otorhinolaryngol. 2006 Jun;263(6):532-6. doi: 10.1007/s00405-005-0006-6. Epub 2006 Mar 25.
7
Complications of percutaneous radiofrequency ablation for hepato-cellular carcinoma: imaging spectrum and management.肝细胞癌经皮射频消融的并发症:影像谱与处理
Radiographics. 2005 Oct;25 Suppl 1:S57-68. doi: 10.1148/rg.25si055505.
8
Radiofrequency ablation: importance of background tissue electrical conductivity--an agar phantom and computer modeling study.射频消融:背景组织电导率的重要性——一项琼脂模型与计算机建模研究
Radiology. 2005 Aug;236(2):495-502. doi: 10.1148/radiol.2362040965.
9
Image-guided tumor ablation: standardization of terminology and reporting criteria.图像引导下的肿瘤消融:术语和报告标准的标准化
J Vasc Interv Radiol. 2005 Jun;16(6):765-78. doi: 10.1097/01.RVI.0000170858.46668.65.
10
[Percutaneous thermoablation of pulmonary metastases. Experience with the application of laser-induced thermotherapy (LITT) and radiofrequency ablation (RFA), and a literature review].[经皮热消融治疗肺转移瘤。激光诱导热疗(LITT)和射频消融(RFA)的应用经验及文献综述]
Rofo. 2004 Nov;176(11):1658-66. doi: 10.1055/s-2004-813465.