Siniscalco Dario
Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Naples, Italy.
Methods Mol Biol. 2010;617:337-45. doi: 10.1007/978-1-60327-323-7_25.
Neuropathic pain is a complex disease that involves several molecular pathways. Due to its individual character, the treatment of neuropathic pain is extremely difficult. Currently available drugs do not affect the mechanisms underlying the generation and propagation of pain. Therefore, pain research is now focused on molecular approaches such as stem cell therapy. Stem cells mediate neuroprotection in a variety of nervous system injury models. We used spared nerve injury (SNI) model of neuropathic pain to assess the possible use of human mesenchymal stem cells (hMSCs) as neuroprotective tool in the regenerative medicine. We conclude that stem cell transplantation could be a useful therapeutic tool in the future of regenerative medicine.
神经性疼痛是一种涉及多种分子途径的复杂疾病。由于其个体特性，神经性疼痛的治疗极其困难。目前可用的药物并不影响疼痛产生和传播的潜在机制。因此，疼痛研究目前集中在诸如干细胞疗法等分子方法上。干细胞在多种神经系统损伤模型中介导神经保护作用。我们使用神经性疼痛的 spared 神经损伤（SNI）模型来评估人间充质干细胞（hMSCs）作为再生医学中神经保护工具的可能用途。我们得出结论，干细胞移植可能成为再生医学未来一种有用的治疗工具。
