Schluesener H J
Department of Neurology, University of Wuerzburg, Federal Republic of Germany.
J Neurosci Res. 1991 Feb;28(2):310-4. doi: 10.1002/jnr.490280218.
The transforming growth factors type beta 1, beta 2, and beta 1.2 suppress multidrug transport in human pat-1 glioblastoma cells and even in cells that strongly over-express mdr genes and are resistant to inhibition of multidrug transport by chemosensitizers. Thus, inhibition of multidrug transport by cytokines might be a new approach to increase cellular accumulation of chemotherapeutic agents in multidrug resistant glial tumor cells. Interestingly, a member of the more distantly related decapentaplegic subgroup of transforming growth factors, the bone morphogenetic protein BMP 2, did not inhibit multidrug transport.
转化生长因子β1、β2和β1.2抑制人pat-1胶质母细胞瘤细胞中的多药转运，甚至在那些强烈过表达mdr基因且对化学增敏剂抑制多药转运具有抗性的细胞中也有此作用。因此，细胞因子抑制多药转运可能是增加多药耐药性胶质肿瘤细胞中化疗药物细胞内蓄积的一种新方法。有趣的是，转化生长因子中关系较远的双胸蛋白亚组的一个成员，骨形态发生蛋白BMP 2，并不抑制多药转运。
