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Spontaneous multidrug transport in human glioma cells is regulated by transforming growth factors type beta.

作者信息

Schluesener H J, Meyermann R

机构信息

Abteilung für Neurologie, Universität Würzburg, Federal Republic of Germany.

出版信息

Acta Neuropathol. 1991;81(6):641-8. doi: 10.1007/BF00296374.

DOI:10.1007/BF00296374
PMID:1679277
Abstract

The multidrug transporting cell membrane molecule P-glycoprotein can be spontaneously expressed in human glioma cells. Transcripts of mdr genes were detected in glial tumor cells by polymerase chain reaction and Northern blotting, expression of P-glycoprotein was analyzed by immunocytochemistry and functional activity by cytofluorometry of fluorescent probe transport. In vitro treatment of glioma cells with vincristine induced coordinate over-expression of both mdr1 and mdr3 genes associated with very high P-glycoprotein-mediated multidrug transport, resistant to the inhibitory activity of chemosensitizers like verapamil. The physiological modulators of multidrug transport are as yet unknown. We therefore initiated a screening program to analyze the effects of cytokines on multidrug transport. We observed, that transforming growth factors (TGF)-beta 1, -beta 2, and -beta 1.2-but not the related bone morphogenetic protein (BMP) 2--inhibited multidrug transport. Interestingly, BMP 2 antagonized the TGF-beta induced inhibition of multidrug transport.

摘要

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Cross-resistance to rhodamine 123 in Adriamycin- and daunorubicin-resistant Friend leukemia cell variants.阿霉素和柔红霉素耐药的Friend白血病细胞变体对罗丹明123的交叉耐药性。
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Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.人类“MDR1”基因全长cDNA的表达赋予了对秋水仙碱、阿霉素和长春花碱的抗性。
Proc Natl Acad Sci U S A. 1987 May;84(9):3004-8. doi: 10.1073/pnas.84.9.3004.
7
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.在多药耐药性KB癌细胞中扩增的人多药耐药基因（mdr）DNA序列的分离
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4538-42. doi: 10.1073/pnas.83.12.4538.
8
Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.人类多药耐药细胞系：多药耐药基因1（mdr1）表达增加可先于基因扩增出现。
Science. 1986 May 2;232(4750):643-5. doi: 10.1126/science.3457471.
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Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection.逆转录病毒介导的多药耐药小鼠cDNA转移可使细胞在未经预先药物筛选的情况下产生多药耐药性。
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