Schluesener H J
Department of Neurology, University of Wuerzburg, FRG.
Autoimmunity. 1991;9(3):269-75. doi: 10.3109/08916939109007653.
Astrocytes--like some endothelial cells of the blood-brain barrier--can express a multidrug transport system, which limits the intracellular accumulation of cytostatic agents and a variety of other substances. I observed that astrocytic multidrug transport can be modulated by cytokines: The transforming growth factors type beta 1, beta 2, and beta 1,2 are specific inhibitors of multidrug transport in fetal rat brain astrocyte cell lines. Other cytokines or interleukins did not inhibit astrocytic multidrug transport. Interestingly, the inhibitory effect of TGF-beta could be antagonized by the bone morphogenetic protein BMP 2, a cytokine that is distantly related to TGF-beta.
星形胶质细胞——就像血脑屏障的一些内皮细胞一样——可以表达一种多药转运系统，该系统会限制细胞毒性药物和多种其他物质在细胞内的积累。我观察到星形胶质细胞的多药转运可被细胞因子调节：转化生长因子β1、β2和β1,2是胎鼠脑星形胶质细胞系中多药转运的特异性抑制剂。其他细胞因子或白细胞介素不会抑制星形胶质细胞的多药转运。有趣的是，转化生长因子β的抑制作用可被骨形态发生蛋白BMP 2拮抗，骨形态发生蛋白BMP 2是一种与转化生长因子β关系较远的细胞因子。
