Department of Chemistry, Faculty Science and Mathematics, Universitas Diponegoro, Jl. Prof. H. Soedarto, S.H., Tembalang, Semarang, Jawa Tengah, Indonesia.
Department of Chemistry, Faculty Science and Mathematics, Universitas Diponegoro, Jl. Prof. H. Soedarto, S.H., Tembalang, Semarang, Jawa Tengah, Indonesia.
Int J Biol Macromol. 2020 Jun 1;152:633-644. doi: 10.1016/j.ijbiomac.2020.02.290. Epub 2020 Feb 26.
In this study, improvement of urea and creatinine permeability of polyethersulfone (PES) membrane by coating with synthesized tripolyphosphate-crosslinked chitosan (TPP-CS) has been conducted. Original and modified membranes, e.g. pristine PES, polyethersulfone-polyethylene glycol (PES-PEG) and PES-PEG/TPP-CS membranes were characterized using FTIR, DTG, SEM, AFM, water uptake, contact angles, porosity measurement, tensile strength test and permeation tests against urea and creatinine. The results show that the PES modification by TPP-CS coating has been successfully carried out. The water uptake ability, hydrophilicity and porosity of the modified membranes increase significantly to a greater degree. All modified membranes have good thermal stability and tensile strength and their permeation ability towards urea and creatinine increase with the increasing concentration of TPP-CS. PES membrane has urea clearance ability of 7.36 mg/dL and creatinine of 0.014 mg/dL; membrane PES-PEG shows urea clearance of 11.87 mg/dL and creatinine of 0.32 mg/dL; while PES-PEG/TPP-CS membrane gives urea clearance of 20.87-36.40 mg/dL and creatinine in the range of 0.52-0.78 mg/dL. These results suggest that the PES-PEG membrane coated with TPP-CS is superior and can be used as potential material for hemodialysis membrane.
本研究通过合成三聚磷酸交联壳聚糖（TPP-CS）对聚醚砜（PES）膜的尿素和肌酐渗透性能进行了改善。使用 FTIR、DTG、SEM、AFM、吸水率、接触角、孔隙率测量、拉伸强度测试和对尿素和肌酐的渗透测试对原始和改性膜（例如原始 PES、聚醚砜-聚乙二醇（PES-PEG）和 PES-PEG/TPP-CS 膜）进行了表征。结果表明，成功地进行了 TPP-CS 涂层对 PES 的修饰。改性膜的吸水率、亲水性和孔隙率显著增加。所有改性膜均具有良好的热稳定性和拉伸强度，其对尿素和肌酐的渗透能力随 TPP-CS 浓度的增加而增加。PES 膜对尿素的清除能力为 7.36mg/dL，对肌酐的清除能力为 0.014mg/dL；PES-PEG 膜对尿素的清除能力为 11.87mg/dL，对肌酐的清除能力为 0.32mg/dL；而 PES-PEG/TPP-CS 膜对尿素的清除能力为 20.87-36.40mg/dL，对肌酐的清除能力为 0.52-0.78mg/dL。这些结果表明，用 TPP-CS 涂层的 PES-PEG 膜具有优越性，可作为潜在的血液透析膜材料。
