Japiassú Ricardo M, Moura Brasil Oswaldo F, de Souza Eduardo C
Ophthalmic Surg Lasers Imaging. 2010 Mar 9:1-3. doi: 10.3928/15428877-20100215-34.
Cavernous hemangioma of the retina is an unusual vascular hamartoma that has been reported to occur either sporadically or as a dominantly inherited trait. A case of a large and sporadic macular cavernous hemangioma that was successfully treated with systemic infliximab as a first line of treatment is presented. The patient was referred with decreased vision of the right eye for 6 months. Fundus examination disclosed a reddish elevated lesion in the posterior pole that obscured the macula and encroached on the fovea. It consisted of grapelike aneurysms. The patient underwent treatment with infliximab intravenously. Two weeks after the second infusion of infliximab, visual acuity improved to 20/80 with a marked involution of the tumor in the right eye. Although the data are limited, we think that a new perspective for treatment of retinal vascular tumors may appear in the future considering antibodies to tumor necrosis factor (TNF)-alpha.
视网膜海绵状血管瘤是一种罕见的血管错构瘤，据报道其发病可为散发性或显性遗传特征。本文报告一例大型散发性黄斑海绵状血管瘤，作为一线治疗方案，采用英夫利昔单抗全身治疗获得成功。该患者因右眼视力下降6个月前来就诊。眼底检查发现后极部有一红色隆起病变，遮挡黄斑并侵犯中央凹，病变由葡萄状动脉瘤组成。患者接受了英夫利昔单抗静脉治疗。第二次输注英夫利昔单抗两周后，右眼视力提高到20/80，肿瘤明显消退。尽管数据有限，但我们认为，考虑到肿瘤坏死因子（TNF）-α抗体，未来可能会出现治疗视网膜血管肿瘤的新视角。
