Division of Standard Research, Korea Institute of Oriental Medicine, Daejeon, South Korea.
Acta Ophthalmol. 2011 Mar;89(2):101-6. doi: 10.1111/j.1755-3768.2009.01855.x.
The objective of this review was to assess the effectiveness of acupuncture as a treatment option for treating the condition of dry eye.
We searched the literature using 14 databases from their inceptions to 3 December 2009, without language restrictions. We included randomized clinical trials (RCTs) comparing acupuncture with conventional treatment. Their risk of bias was assessed using Cochrane criteria.
Six RCTs met all the inclusion criteria. Three RCTs compared the effects of acupuncture with artificial tears in patients with xerophthalmia or Sjögren syndrome. A meta-analysis of these data showed that acupuncture improved tear break-up times (p < 0.0001), Schirmer test scores (p < 0.00001), response rates (p = 0.002) and the region of cornea fluorescent staining (p = 0.0001) significantly more than artificial tears did. The other three RCTs compared the effects of acupuncture plus artificial tears with artificial tears alone. Two of these studies failed to show significant effects of acupuncture, while one reported significant effects. For Schirmer test scores and frequency of artificial tear usage, two RCTs reported superior effects of acupuncture plus artificial tears, while one RCT failed to do so.
These results provide limited evidence for the effectiveness of acupuncture for treating dry eye. However, the total number of RCTs, the total sample size and the methodological quality were too low to draw firm conclusions.
本综述旨在评估针灸作为治疗干眼症的一种治疗方法的有效性。
我们从数据库建立之初至 2009 年 12 月 3 日，无语言限制地检索了 14 个数据库中的文献。我们纳入了比较针灸与常规治疗的随机临床试验（RCT）。使用 Cochrane 标准评估其偏倚风险。
6 项 RCT 完全符合所有纳入标准。3 项 RCT 比较了针灸与人工泪液治疗干眼症或干燥综合征患者的疗效。对这些数据的荟萃分析显示，针灸明显改善了泪膜破裂时间（p < 0.0001）、泪液分泌试验评分（p < 0.00001）、应答率（p = 0.002）和角膜荧光染色区域（p = 0.0001）。另外 3 项 RCT 比较了针灸联合人工泪液与单纯人工泪液的疗效。其中两项研究未能显示针灸的显著效果，而一项研究则报告了显著效果。对于泪液分泌试验评分和人工泪液使用频率，两项 RCT 报告针灸联合人工泪液的效果更佳，而一项 RCT 则未能做到这一点。
这些结果为针灸治疗干眼症的有效性提供了有限的证据。然而，RCT 的总数、总样本量和方法学质量都太低，无法得出明确的结论。
