Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Anaesthesia. 2010 May;65(5):500-4. doi: 10.1111/j.1365-2044.2010.06310.x. Epub 2010 Mar 19.
We compared the prophylactic anti-emetic efficacy of ramosetron, a newly developed 5-HT(3) antagonist, and ondansetron in patients at high-risk for postoperative nausea and vomiting after total knee replacement. Eighty-four patients with three risk factors for postoperative nausea and vomiting (female, non-smoking and use of postoperative opioid use (ropivacaine and hydromorphone patient controlled epidural analgesia)) undergoing unilateral total knee replacement were randomly allocated to ramosetron 0.3 mg (n = 42) or ondansetron 4 mg (n = 42) groups. A complete response (no postoperative nausea and vomiting and no rescue anti-emetic) and the incidence of postoperative nausea and vomiting were assessed for 48 h after surgery at 0-2 h, 2-6 h, 6-24 h, and 24-48 h. More patients in the ramosetron group had a complete response between 2 and 48 h. The incidence of nausea between 2 and 24 h and the severity of nausea between 2 and 48 h were also less in the ramosetron group. Ramosetron was more effective than ondansetron in preventing postoperative nausea and vomiting in patients at high risk undergoing unilateral total knee replacement.
我们比较了雷莫司琼（一种新开发的 5-HT3 拮抗剂）和昂丹司琼在全膝关节置换术后恶心和呕吐高危患者中的预防止吐效果。84 例有 3 个术后恶心和呕吐危险因素（女性、不吸烟和使用术后阿片类药物（罗哌卡因和氢吗啡酮患者自控硬膜外镇痛）的单侧全膝关节置换术患者被随机分配到雷莫司琼 0.3mg 组（n=42）或昂丹司琼 4mg 组（n=42）。在手术后 0-2 小时、2-6 小时、6-24 小时和 24-48 小时评估 48 小时内完全缓解（无术后恶心和呕吐且无解救性止吐）和术后恶心和呕吐的发生率。雷莫司琼组在 2 至 48 小时之间有更多的患者出现完全缓解。雷莫司琼组在 2 至 24 小时之间的恶心发生率和 2 至 48 小时之间的恶心严重程度也较低。在接受单侧全膝关节置换术的高危患者中，雷莫司琼比昂丹司琼更能有效预防术后恶心和呕吐。
