Ministry of Health, Republic of the Marshall Islands.
J Public Health Dent. 2010 Summer;70(3):249-52. doi: 10.1111/j.1752-7325.2010.00163.x.
This communication examines the combined effect of topical polyvinylpyrollidone (PVP)-iodine plus fluoride varnish in the prevention of tooth decay in erupting first permanent molars in an ongoing public health program.
The evaluation employed a retrospective cohort design with two groups of children 60-83 months. Cohort 1 (2004-05) received three times per school year topical fluoride varnish, and Cohort 2 (2008-09) received topical application of 10 percent PVP-iodine followed at each visit with topical fluoride varnish. The children were examined clinically at the beginning and end of the school year.
The proportion of children with caries-free first permanent molars in Cohort 2 (PVP-iodine plus fluoride varnish) was 0.883 and was greater than that in Cohort 1 (varnish), which was 0.785 (Chi-square = 1.000E1, df 1, P < 0.002).
This evaluation of an ongoing dental public health program adds evidence that topical antiseptics applied at the same time as fluoride varnish are more effective than varnish alone. Randomized trials are needed.
本研究旨在探讨在持续进行的公共卫生项目中，局部使用聚乙烯吡咯烷酮碘（PVP-碘）联合氟化物涂料对萌出的第一恒磨牙龋齿预防的联合作用。
本研究采用回顾性队列设计，纳入两组 60-83 月龄的儿童。队列 1（2004-05 年）每年接受 3 次局部氟化物涂料治疗，队列 2（2008-09 年）每次就诊时先给予 10%PVP-碘局部应用，然后再给予局部氟化物涂料。在学年开始和结束时，对儿童进行临床检查。
队列 2（PVP-碘联合氟化物涂料）中无龋第一恒磨牙的儿童比例为 0.883，高于队列 1（仅用涂料）的 0.785（卡方=1.000E1，df 1，P<0.002）。
本项对正在进行的口腔公共卫生项目的评估结果增加了证据，即同时使用局部防腐剂和氟化物涂料比单独使用涂料更有效。需要进行随机试验。
