Zhan Ling, Featherstone John D B, Gansky Stuart A, Hoover Charles I, Fujino Tamaki, Berkowitz Robert J, Den Besten Pamela K
Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA 476-0926 USA.
J Public Health Dent. 2006 Summer;66(3):174-9. doi: 10.1111/j.1752-7325.2006.tb02576.x.
To assess the effects of a single 10% povidone iodine application as an adjunct to extensive surgical procedures in the clinical treatment of children with early childhood caries.
Twenty-two children scheduled for dental treatment under general anesthesia were randomized into either an intervention group (10% povidone iodine), or a control group (phosphate buffered saline). Either povidone iodine or phosphate buffered saline was applied to teeth and soft tissues after prophylaxis and all operative dental procedures, followed by 1.23% acidulated phosphate fluoride gel. Saliva samples taken at baseline, and after 1 hour, 3 weeks and 3 months were assayed for mutans streptococci, lactobacilli and total viable bacteria. Caries lesions were recorded at baseline and at one year.
Mutans streptococci and lactobacilli levels in the povidone iodine group were significantly reduced relative to baseline at 1 hour, 3 weeks and 3 months. At one year at least 60% of subjects had new caries lesions in each group, and there was no significant difference in caries increment between the two groups.
Even prophylaxis, fluoride gel application and complete surgical treatment of caries at baseline were insufficient to prevent new caries in over 60% of the patients in these high caries risk infants. Although the one-time treatment with povidone iodine reduced mutans streptococci and lactobacilli levels for up to 3 months this therapy failed to additionally reduce future caries formation over one year, indicating that repeated antibacterial treatments will be needed to control high levels of cariogenic bacteria.
评估单次应用10%聚维酮碘作为辅助手段在幼儿早期龋齿患儿临床广泛外科手术治疗中的效果。
22名计划在全身麻醉下接受牙科治疗的儿童被随机分为干预组（10%聚维酮碘）或对照组（磷酸盐缓冲盐水）。在预防性治疗和所有牙科手术操作后，将聚维酮碘或磷酸盐缓冲盐水应用于牙齿和软组织，随后使用1.23%的酸化磷酸氟凝胶。在基线、1小时、3周和3个月后采集唾液样本，检测变形链球菌、乳酸菌和总活菌数。在基线和一年时记录龋损情况。
聚维酮碘组的变形链球菌和乳酸菌水平在1小时、3周和3个月时相对于基线显著降低。一年时，每组至少60%的受试者出现新的龋损，两组之间的龋损增量无显著差异。
即使在基线时进行预防性治疗、应用氟凝胶以及对龋齿进行全面外科治疗，也不足以预防这些高龋风险婴儿中超过60%的患者出现新龋。尽管单次聚维酮碘治疗可使变形链球菌和乳酸菌水平降低长达3个月，但该疗法未能在一年时间内额外减少未来龋齿的形成，这表明需要反复进行抗菌治疗以控制高水平的致龋菌。
