Amin Maryam S, Harrison Rosamund L, Benton Tonya S, Roberts Marilyn, Weinstein Philip
Department of Oral Health Sciences, University of British Columbia, Canada.
Pediatr Dent. 2004 Jan-Feb;26(1):5-10.
The purpose of this pilot project was to determine the effect of a 10% povidone-iodine solution on plaque Streptococcus mutans and on incidence of new caries in young children following dental rehabilitation under general anesthesia.
Twenty-five children ages 2 to 7 years, scheduled for dental treatment under general anesthesia, were enrolled. Children in the experimental group (N = 13) had povidone-iodine applied 3 times at 2-month intervals. Control children (N = 12) had no treatment. Plaque samples were taken from all children at baseline, 6 months and cultured for total bacteria and S mutans. Dental examinations were conducted at baseline, 6 months, and 1 year.
Experimental and control children had similar dietary habits, caries experience, and S mutans levels at baseline. All children's S mutans counts decreased significantly at 6 months (P = .003). The difference between the 2 groups was not significant (P = .58). At 1 year, 5 of 8 children in the control group had new caries compared to 2 of 11 children in the experimental group (P = .06). Povidone-iodine was well accepted by participating families.
Extensive one-time restorative dental treatment resulted in a significant suppression S mutans levels at 6 months. Further exploration of the role of povidone-iodine in caries management is indicated.
本试点项目的目的是确定10%聚维酮碘溶液对菌斑变形链球菌以及对全麻下进行牙齿修复的幼儿新发龋齿发生率的影响。
招募了25名2至7岁计划在全麻下接受牙科治疗的儿童。实验组（N = 13）的儿童每隔2个月应用3次聚维酮碘。对照组儿童（N = 12）未接受治疗。在基线、6个月时从所有儿童采集菌斑样本，培养总细菌和变形链球菌。在基线、6个月和1年时进行牙科检查。
实验组和对照组儿童在基线时饮食习惯、龋齿经历和变形链球菌水平相似。所有儿童的变形链球菌计数在6个月时显著下降（P = .003）。两组之间的差异不显著（P = .58）。在1年时，对照组8名儿童中有5名出现新发龋齿，而实验组11名儿童中有2名出现新发龋齿（P = .06）。聚维酮碘得到了参与家庭的良好接受。
广泛的一次性修复性牙科治疗在6个月时导致变形链球菌水平显著抑制。表明需要进一步探索聚维酮碘在龋齿管理中的作用。
