Division of Respirology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Pediatr Allergy Immunol. 2010 Jun;21(4 Pt 2):e740-6. doi: 10.1111/j.1399-3038.2010.01021.x. Epub 2010 Mar 19.
Contradictory findings have been observed for the association of house dust mite (HDM), cat, and dog allergen exposure with sensitization and asthma. We sought to determine the relationship between exposures to these allergens, at various points during early childhood, and specific sensitization and asthma at age 7 in a high-risk birth cohort. As part of a multi-faceted Canadian intervention program for the primary prevention of asthma in high-risk infants, children were assessed by pediatric allergists at age 7 for asthma and underwent allergy skin prick testing. House dust samples were analyzed for HDM, cat, and dog allergen levels at several time points during years 1 and 7 of life. Multiple logistic regression analyses were carried out for the combined cohort and separately for the control and intervention groups. Exposure to a higher level of HDM allergen in year 1 or year 7 was associated with a higher risk of year 7 sensitization to HDM but not asthma. Exposure to higher levels of cat allergen in year 1 or year 7 did not affect the risk of year 7 sensitization to cat or asthma. Dog ownership, or exposure to higher levels of dog allergen in year 1 or year 7, did not affect the risk of year 7 sensitization to dog; however, year 7 dog allergen exposure (intervention group only) or ownership was associated with increased year 7 asthma risk. Our findings suggest that in high-risk children, there are allergen-specific associations of exposure with sensitization and with asthma; early life-elevated HDM exposure was associated with risk of sensitization but not asthma while the opposite was true for dog exposure.
对于屋尘螨（HDM）、猫和狗过敏原暴露与致敏和哮喘的关联，观察到了相互矛盾的结果。我们试图确定在高危出生队列中，这些过敏原在儿童早期的不同时间点暴露与 7 岁时特定致敏和哮喘之间的关系。作为针对高危婴儿的哮喘初级预防的加拿大多方面干预计划的一部分，儿童在 7 岁时由儿科过敏专家评估哮喘，并进行过敏皮肤点刺试验。在生命的第 1 年和第 7 年的几个时间点分析屋尘样本以测量 HDM、猫和狗过敏原水平。对合并队列以及对照组和干预组分别进行了多项逻辑回归分析。第 1 年或第 7 年暴露于更高水平的 HDM 过敏原与第 7 年对 HDM 的致敏风险增加有关，但与哮喘无关。第 1 年或第 7 年暴露于更高水平的猫过敏原不会影响第 7 年对猫的致敏或哮喘风险。第 1 年或第 7 年拥有狗或暴露于更高水平的狗过敏原不会影响第 7 年对狗的致敏风险；然而，第 7 年狗过敏原暴露（仅干预组）或拥有与第 7 年哮喘风险增加有关。我们的研究结果表明，在高危儿童中，暴露与致敏和哮喘存在特定的过敏原关联；生命早期 HDM 暴露增加与致敏风险有关，但与哮喘无关，而狗暴露则相反。
