乳腺黏液性囊腺癌，HER2 基因扩增经 FISH 证实：首例报道。
Mucinous cystadenocarcinoma of the breast with amplification of the HER2-gene confirmed by FISH: The first case reported.
机构信息
Department of Pathology, National University Health System, Singapore 119074, Singapore.
出版信息
Hum Pathol. 2010 Jun;41(6):910-3. doi: 10.1016/j.humpath.2009.10.020. Epub 2010 Mar 24.
Abstract
We present the first case of a primary mucinous cystadenocarcinoma of the breast that, in addition to the characteristic immunophenotype (CK7(+), CK20(-), ER(-), PR(-), and cdx2(-)), showed a strong membranous HER2-protein expression and HER2-gene amplification documented by fluorescence in situ hybridization.
摘要
我们报告首例乳腺原发性黏液囊腺癌病例，该病例除了具有特征性的免疫表型（CK7(+)，CK20(-)，ER(-)，PR(-)和 cdx2(-)）外，还显示出强膜 HER2 蛋白表达和荧光原位杂交证实的 HER2 基因扩增。
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