Reproductive and Vascular Biology Group, Institute of Cellular Medicine and School of Medical Development and Education, Newcastle University, Newcastle upon Tyne, UK.
Placenta. 2010 Jun;31(6):545-8. doi: 10.1016/j.placenta.2010.02.020. Epub 2010 Mar 24.
Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth factors were measured by multiplex growth factor analysis or ELISA in tissue culture supernatants from EVT and CTB from pregnancies at 8-10 and 12-14 weeks' gestation. Gestational age and cell type differences were observed. EVT and CTB are major producers of angiogenic growth factors that likely contribute to placental vascular development and spiral artery remodeling.
血管生成是妊娠早期胎盘和子宫发育的关键特征。我们假设滋养细胞产生血管生成生长因子，并且在绒毛细胞滋养层（CTB）和绒毛外滋养细胞（EVT）细胞之间表达不同。通过多重生长因子分析或 ELISA 测量了妊娠 8-10 周和 12-14 周时 EVT 和 CTB 组织培养上清液中的 14 种血管生成生长因子。观察到了胎龄和细胞类型的差异。EVT 和 CTB 是血管生成生长因子的主要产生者，可能有助于胎盘血管发育和螺旋动脉重塑。
