Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, Louisiana.
Reproductive Endocrinology & Women's Health Lab, Pennington Biomedical Research Center , Baton Rouge, Louisiana.
Physiol Genomics. 2019 Mar 1;51(3):73-76. doi: 10.1152/physiolgenomics.00102.2018. Epub 2019 Feb 4.
Preeclampsia (PE) is a devastating adverse outcome of pregnancy. Characterized by maternal hypertension, PE, when left untreated, can result in death of both mother and baby. The cause of PE remains unknown, and there is no way to predict which women will develop PE during pregnancy. The only known treatment is delivery of both the fetus and placenta; therefore, an abnormal placenta is thought to play a causal role. Women with obesity before pregnancy have an increased chance of developing PE. Increased adiposity results in a heightened state of systemic inflammation that can influence placental development. Adipose tissue is a rich source of proinflammatory cytokines and complement proteins, which have been implicated in the pathogenesis of PE by promoting the expression of antiangiogenic factors in the mother. Because an aggravated inflammatory response, angiogenic imbalance, and abnormal placentation are observed in PE, we hypothesize that maternal obesity and complement proteins derived from adipose tissue play an important role in the development of PE.
子痫前期 (PE) 是妊娠的一种严重不良结局。其特征为母体高血压，如果不加以治疗，可能会导致母婴死亡。PE 的病因仍不清楚，也无法预测哪些女性在怀孕期间会患上 PE。唯一已知的治疗方法是分娩胎儿和胎盘；因此，异常胎盘被认为起着因果关系。孕前肥胖的女性患 PE 的几率增加。肥胖会导致全身性炎症状态加剧，从而影响胎盘发育。脂肪组织是促炎细胞因子和补体蛋白的丰富来源，这些细胞因子和蛋白通过在母体中促进抗血管生成因子的表达，参与了 PE 的发病机制。由于在 PE 中观察到炎症反应加剧、血管生成失衡和胎盘异常，我们假设母体肥胖和来自脂肪组织的补体蛋白在 PE 的发展中起着重要作用。
