在白血病浆细胞样树突状细胞系（PMDC05）中，树突状细胞从浆细胞样向髓样的转化。
Transformation of dendritic cells from plasmacytoid to myeloid in a leukemic plasmacytoid dendritic cell line (PMDC05).
机构信息
Laboratory of Hematology and Oncology, Graduate School of Health Sciences, Niigata University, Niigata, Japan.
出版信息
Leuk Res. 2010 Nov;34(11):1517-24. doi: 10.1016/j.leukres.2010.03.002. Epub 2010 Mar 24.
We investigated the transformation from pDCs to mDCs in a pDC line (PMDC05) which was established from a patient with pDC leukemia in our laboratory. PMDC05 cells were separated into two fractions according to the expression of BDCA1 and CD123. BDCA1(-)CD123(+) cells were found to be pDC-like cells by their morphology, surface phenotypes, mRNA expression and the function. In addition, BDCA1(-)CD123(+) cells were demonstrated to have a proliferating capacity and revealed the ability to transform to BDCA1(+)CD123(-) cells which showed mDC-like properties. Our data demonstrated the possibility of transformation from pDCs to mDCs in human DC lineage.
我们研究了本实验室建立的一名浆细胞样树突状细胞白血病患者来源的 pDC 系（PMDC05）中 pDC 向 mDC 的转化。PMDC05 细胞根据 BDCA1 和 CD123 的表达分为两部分。BDCA1(-)CD123(+)细胞通过形态、表面表型、mRNA 表达和功能表现出 pDC 样细胞的特征。此外，BDCA1(-)CD123(+)细胞被证明具有增殖能力，并显示出转化为具有 mDC 样特性的 BDCA1(+)CD123(-)细胞的能力。我们的数据表明在人类 DC 谱系中 pDC 向 mDC 转化的可能性。
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