Division of Nephrology, Department of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan.
Perit Dial Int. 2010 May-Jun;30(3):320-8. doi: 10.3747/pdi.2009.00118. Epub 2010 Mar 25.
There have been no reports on peritoneal dialysis (PD) solution utilization since this treatment was developed in the 1920s. The aim of the present investigation was to investigate if weather affects PD prescription.
This 10-year observational study used the Taiwan National Health Insurance Research Database.
Claims for different concentrate PD dialysate were analyzed monthly. 2.5% and 4.25% PD solutes were defined as hypertonic solutions.
Monthly outdoor mean temperature. Outcome and Measurement: The relationship between monthly mean of PD dialysate utilization and monthly outdoor temperature was analyzed by linear regression. Monthly mean PD dialysate utilization amount in 4 quarters was analyzed by ANOVA.
During the 10-year study period, a clear seasonal variation in PD dialysate was observed. This seasonal variation was present regardless of age, gender, and the presence of hypertension, diabetes, and dyslipidemia. Monthly mean temperature was positively correlated to 1.5% dialysate utilization amount (r = 0.559, p < 0.001) and negatively correlated to 2.5% (r = -0.533, p < 0.001) and 4.25% (r = -0.410, p < 0.001) dialysate utilization amount. In longitudinal follow-up, hypertonic PD fluid utilization was higher in diabetic patients than in nondiabetic patients from the beginning of treatment. Thereafter, it increased rapidly and reached a plateau within 1 year.
Analysis of ultrafiltration amount, blood pressure, and body weight was unfeasible due to the nature of the database.
The utilization of differential strengths of PD solutions has a seasonal cyclic pattern, with more hypertonic PD solution utilized in winter and more hypotonic PD solution in summer.
自 20 世纪 20 年代开展腹膜透析（PD）治疗以来，尚无 PD 溶液使用情况的相关报告。本研究旨在探讨天气是否会影响 PD 处方。
这是一项为期 10 年的观察性研究，使用了台湾全民健康保险研究数据库。
每月分析不同浓缩 PD 透析液的使用情况。2.5%和 4.25% PD 溶质被定义为高渗溶液。
每月室外平均温度。
采用线性回归分析每月 PD 透析液使用量与每月室外温度之间的关系。采用方差分析（ANOVA）分析 4 个季度的每月平均 PD 透析液使用量。
在 10 年的研究期间，观察到 PD 透析液有明显的季节性变化。这种季节性变化与年龄、性别以及高血压、糖尿病和血脂异常的存在无关。每月平均温度与 1.5%透析液使用量呈正相关（r = 0.559，p < 0.001），与 2.5%（r = -0.533，p < 0.001）和 4.25%（r = -0.410，p < 0.001）透析液使用量呈负相关。在纵向随访中，糖尿病患者从治疗开始时就比非糖尿病患者使用更多的高渗 PD 液。此后，其用量迅速增加，并在 1 年内达到平台期。
由于数据库的性质，无法分析超滤量、血压和体重。
不同强度 PD 溶液的使用具有季节性循环模式，冬季使用更多高渗 PD 溶液，夏季使用更多低渗 PD 溶液。
