Yu Zanzhe, Ding Li, He Yanna, Huang Jiaying, Fang Wei, Gu Leyi, Ni Zhaohui, Wang Qin
Department of Nephrology, Molecular Cell Lab for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Renji Hospital, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Physiol. 2023 Jul 27;14:1172308. doi: 10.3389/fphys.2023.1172308. eCollection 2023.
Seasonal variation has an impact on plants, wild animals, and also human beings. Data have shown seasonal variation has a significant impact on patients' fluid status, biochemistry results, and outcomes in hemodialysis populations. The relevant data on peritoneal dialysis is scant. This was a cross sectional study. All patients followed up in our center had a peritoneal equilibration test and PD adequacy test every 6 months. All the peritoneal equilibration test and PD adequacy test data were collected during December 2019 to November 2020. The monthly delivery information of the whole center was collected from 2015 to 2019. There were 366 patients and 604 sets of peritoneal equilibration test and PD adequacy test results in the study. Plasma albumin and phosphate levels were higher in summer. The monthly average outdoor temperature was positively correlated with plasma albumin. There was no seasonal difference in peritoneal dialysis ultrafiltration or urine volume. The percentage of low glucose concentration (1.5%) usage was higher in summer and lower in winter. Plasma albumin and phosphate levels were higher in summer in PD patients. Weaker glucose peritoneal dialysis dialysate was more widely used in summer. Understanding the seasonal variation of peritoneal dialysis is helpful in individualized treatment.
季节变化对植物、野生动物乃至人类都会产生影响。数据表明，季节变化对血液透析人群的患者体液状态、生化指标及预后有显著影响。而关于腹膜透析的相关数据则较为匮乏。
这是一项横断面研究。在我们中心接受随访的所有患者每6个月进行一次腹膜平衡试验和腹膜透析充分性检测。所有腹膜平衡试验和腹膜透析充分性检测数据均在2019年12月至2020年11月期间收集。整个中心2015年至2019年的月度透析液交付信息也被收集。
本研究共有366例患者，604组腹膜平衡试验和腹膜透析充分性检测结果。夏季患者血浆白蛋白和磷酸盐水平较高。月平均室外温度与血浆白蛋白呈正相关。腹膜透析超滤量或尿量无季节差异。低葡萄糖浓度（1.5%）透析液的使用比例夏季较高，冬季较低。腹膜透析患者夏季的血浆白蛋白和磷酸盐水平较高。较弱的葡萄糖腹膜透析液在夏季使用更为广泛。了解腹膜透析的季节变化有助于个体化治疗。
