Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Nephrol Dial Transplant. 2010 Oct;25(10):3236-40. doi: 10.1093/ndt/gfq155. Epub 2010 Mar 25.
The purpose of this study is to investigate the relationship between serum resistin levels and chronic kidney disease (CKD).
A total of 3192 community-dwelling subjects (1377 men, 1815 women), aged ≥40 years and without renal failure, were divided into four groups according to quartiles of serum resistin concentrations: ≤7.1, 7.2-9.9, 10.0-14.7 and ≥14.8 ng/mL. The associations of resistin levels with renal function status were examined cross-sectionally. The estimated glomerular filtration rate (eGFR) was calculated using the equation from the Modification of Diet in Renal Disease Study, and CKD was defined as an eGFR of <60 mL/min/1.73 m(2).
The age- and sex-adjusted mean values of eGFR decreased significantly with elevating quartiles of resistin (P for trend <0.001). The age- and sex-adjusted odds ratios (ORs) for the presence of CKD increased progressively with higher quartiles of resistin. This trend remained robust even after controlling for age, sex, body mass index, diabetes, homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), triglycerides, high-density lipoprotein and total cholesterol, hypertension, current smoking, current drinking, and regular exercise [second quartile: OR 1.44, 95% confidence interval (CI) 1.05-1.99; third quartile: OR 2.15, 95% CI 1.58-2.92; fourth quartile: OR 2.32, 95% CI 1.71-3.16; P for trend <0.001]. In stratified analyses, high resistin level (≥7.2 ng/mL) was a significant relevant factor in CKD, independent of HOMA-IR or hs-CRP level. Conclusion. Our findings suggest that elevated resistin level is significantly associated with the likelihood of CKD in the general Japanese population.
本研究旨在探讨血清抵抗素水平与慢性肾脏病（CKD）之间的关系。
共纳入 3192 名年龄≥40 岁且无肾功能衰竭的社区居民（男 1377 人，女 1815 人），根据血清抵抗素浓度四分位数将其分为四组：≤7.1、7.2-9.9、10.0-14.7 和≥14.8ng/ml。 观察抵抗素水平与肾功能状态的相关性。 采用改良肾脏病饮食研究方程计算肾小球滤过率（eGFR），并将 eGFR<60ml/min/1.73m2定义为 CKD。
年龄和性别校正后的 eGFR 平均值随着抵抗素四分位升高而显著降低（趋势 P<0.001）。 随着抵抗素四分位升高，CKD 的年龄和性别校正比值比（OR）逐渐增加。 即使在控制年龄、性别、体重指数、糖尿病、胰岛素抵抗评估的稳态模型（HOMA-IR）、高敏 C 反应蛋白（hs-CRP）、甘油三酯、高密度脂蛋白和总胆固醇、高血压、 当前吸烟、 当前饮酒和定期运动后，这种趋势仍然存在[第二四分位数：OR 1.44，95%置信区间（CI）1.05-1.99；第三四分位数：OR 2.15，95%CI 1.58-2.92；第四四分位数：OR 2.32，95%CI 1.71-3.16；趋势 P<0.001]。 在分层分析中，高抵抗素水平（≥7.2ng/ml）是 CKD 的一个显著相关因素，与 HOMA-IR 或 hs-CRP 水平无关。 结论。 我们的研究结果表明，在一般日本人群中，升高的抵抗素水平与 CKD 的发生显著相关。
