Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Biomed Mater. 2010 Apr;5(2):25009. doi: 10.1088/1748-6041/5/2/025009. Epub 2010 Mar 25.
The effect of radiation processing and filler morphology on the biodegradation and biomechanical stability of a poly(propylene fumarate)/hydroxyapatite composite was investigated. Radiation processing influenced both cross-linking and biodegradation of the composites. Irradiation with a dose of 3 Mrad resulted in enhanced cross-linking, mechanical properties and a higher storage modulus which are favourable for dimensional stability of the implant. The particle morphology of the added hydroxyapatite in the highly cross-linked state significantly influenced the biomechanical and interfacial stability of the composites. Reorganization of agglomerated hydroxyapatite occurred in the cross-linked polymeric matrix under dynamic mechanical loading under simulated physiological conditions. Such a reorganization may increase the damping characteristics of the composite.
研究了辐射处理和填料形态对聚（富马酸丙烯酯）/羟基磷灰石复合材料的生物降解和生物力学稳定性的影响。辐射处理影响了复合材料的交联和生物降解。辐照剂量为 3 Mrad 会导致交联增强、力学性能提高和储能模量增加，有利于植入物的尺寸稳定性。添加的羟基磷灰石的颗粒形态在高度交联状态下显著影响复合材料的生物力学和界面稳定性。在模拟生理条件下的动态力学加载下，交联聚合物基质中团聚的羟基磷灰石会发生重组。这种重组可能会增加复合材料的阻尼特性。
