快速尿素酶试验在诊断使用 NSAIDs 的患者幽门螺杆菌感染中的准确性。
Accuracy of rapid urease test in diagnosing Helicobacter pylori infection in patients using NSAIDs.
机构信息
Department of Gastroenterology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Saudi J Gastroenterol. 2010 Apr-Jun;16(2):110-2. doi: 10.4103/1319-3767.61238.
BACKGROUND/AIM: This study aimed to determine the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the results of rapid urease test (RUT).
PATIENTS AND METHODS
The study evaluated 210 consecutive patients for the diagnosis of Helicobacter pylori (H. pylori) infection. They were divided into case and control groups based on history of NSAID use (n=70 each). Two biopsy specimens were collected from antrum and corpus of stomach during endoscopy and sent for rapid urease testing and histopathology. Sensitivity, specificity, and accuracy rate of RUT test were compared against histology.
RESULTS
The average age was 55.2+/-12.9 and 43.3+/-12.1 years in the case and control groups, respectively. Among NSAID users, RUT sensitivity, specificity and accuracy rate were all 100%. The sensitivity, specificity and accuracy rate of RUT in patients without history of NSAID use were 97.37, 98.57 and 98.14%, respectively. The overall sensitivity, specificity and accuracy rate of RUT were 98.57, 99.29, and 99.04%, respectively.
CONCLUSION
Our study shows that sensitivity, specificity and accuracy rate of RUT are not affected by NSAID use. Rapid urease test remains a reliable test for diagnosis of H. pylori in patients on NSAIDs.
背景/目的：本研究旨在确定非甾体抗炎药（NSAIDs）对快速尿素酶试验（RUT）结果的影响。
患者和方法
本研究评估了 210 例连续患者的幽门螺杆菌（H. pylori）感染诊断。根据 NSAID 使用史（每组 70 例）将患者分为病例组和对照组。在内镜检查时从胃窦和胃体采集两个活检标本，并进行快速尿素酶检测和组织病理学检查。比较 RUT 试验与组织学的敏感性、特异性和准确性。
结果
病例组和对照组的平均年龄分别为 55.2+/-12.9 岁和 43.3+/-12.1 岁。在 NSAID 使用者中，RUT 的敏感性、特异性和准确性均为 100%。无 NSAID 使用史患者的 RUT 敏感性、特异性和准确性分别为 97.37%、98.57%和 98.14%。RUT 的总体敏感性、特异性和准确性分别为 98.57%、99.29%和 99.04%。
结论
我们的研究表明，RUT 的敏感性、特异性和准确性不受 NSAID 使用的影响。在使用 NSAIDs 的患者中，快速尿素酶试验仍然是一种可靠的 H. pylori 诊断试验。
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