Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Magn Reson Med Sci. 2010;9(1):23-9. doi: 10.2463/mrms.9.23.
We evaluated whether enhancement of the cochlear modiolus could be visualized 24 hours after intratympanic injection of gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) using a 3-dimensional real inversion recovery sequence combined with a 32-channel head coil at 3 tesla. Intratympanic injection of Gd-DTPA has been reported for visualizing endolymphatic hydrops in Meniere's disease, and its use has shown communication between the cochlear perilymph and cerebrospinal fluid in the internal auditory canal. Although the cochlear modiolus has been considered the route for this communication, this has not been confirmed through direct visualization of its enhancement.
We qualitatively and quantitatively evaluated the presence of contrast enhancement in the modiolus in 19 patients with clinically suspected endolymphatic hydrops or hearing loss who underwent imaging as described above.
The contrast ratio (CR) between the cochlear modiolus and cerebellar white matter on the injected side was 1.09+/-1.23, and that on the non-injected side was -0.48+/-0.38 (P<0.01). In all subjects, the CR value was larger on the injected than non-injected side, and enhancement of the cochlear modiolus was also recognized visually.
Intratympanic Gd-DTPA can be administered to visualize enhancement of the cochlear modiolus and may thereby reveal its functional anatomy.
我们评估了在 3 特斯拉下使用三维真实反转恢复序列结合 32 通道头部线圈，在鼓室内注射钆二乙烯五胺五乙酸（Gd-DTPA）后 24 小时，是否可以观察到耳蜗中轴增强。鼓室内注射 Gd-DTPA 已用于可视化梅尼埃病中的内淋巴积水，其使用显示了在内耳通道中耳蜗周围淋巴和脑脊液之间的沟通。虽然耳蜗中轴被认为是这种沟通的途径，但尚未通过直接观察其增强来证实。
我们对 19 例临床疑似内淋巴积水或听力损失的患者进行了上述成像，定性和定量评估了耳蜗中轴增强的存在。
注射侧耳蜗中轴与小脑白质的对比比（CR）为 1.09+/-1.23，非注射侧为-0.48+/-0.38（P<0.01）。在所有受试者中，注射侧的 CR 值大于非注射侧，并且也可以通过视觉识别耳蜗中轴的增强。
鼓室内 Gd-DTPA 可用于可视化耳蜗中轴的增强，从而揭示其功能解剖结构。
