Division of Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Obesity (Silver Spring). 2010 Dec;18(12):2367-73. doi: 10.1038/oby.2010.63. Epub 2010 Mar 25.
In a cross-sectional study design, we test the hypothesis whether childhood obesity is associated with reduced flow rate of stimulated whole saliva and dental caries. Obese adolescents (n = 65) with a mean age of 14.5 years and normal weight subjects (n = 65) with a mean age of 14.2 years were clinically examined with respect to dental caries, visible plaque accumulation (visible plaque index (VPI%)), gingival inflammation in terms of bleeding on probing (BOP%) as well as answered a questionnaire concerning medical history, medication, oral hygiene habits, smoking habits, and sociodemographic background. The flow rate of stimulated whole saliva (ml/min) was determined. BMI was calculated and adjusted for age and gender (BMI-sds). The obese subjects exhibited higher number of decayed surfaces (DS), 0.7 vs. 0.1 (P = 0.008) and lower flow rate of stimulated whole saliva 1.2 vs. 2.0 ml/min (P < 0.001). Of obese patients, 17 subjects had VPI% >25 and 21 had BOP% >25, both compared to only 5 subjects of the normal weight with P values of 0.005 and <0.001, respectively. In a multivariate logistic regression model BMI-sds was significantly associated with the flow rate of stimulated whole saliva less than the median value 1.5 ml/min (P < 0.001; odds ratio (OR) 1.36) as well as with DS (DS >0) (P = 0.002; OR 1.31) and the associations were not found to be confounded by any of the studied variables. The results indicate that childhood obesity is associated with reduced flow rate of stimulated whole saliva and dental caries and further strengthens obesity's negative effect on children's oral health.
在一项横断面研究设计中，我们检验了假设，即儿童肥胖是否与刺激全唾液流速降低和龋齿有关。肥胖青少年（n=65）平均年龄为 14.5 岁，正常体重受试者（n=65）平均年龄为 14.2 岁，临床检查龋齿、可见牙菌斑积聚（可见牙菌斑指数（VPI%））、探诊出血（BOP%）的牙龈炎症以及回答有关病史、用药、口腔卫生习惯、吸烟习惯和社会人口学背景的问卷。刺激全唾液流速（ml/min）。计算 BMI 并按年龄和性别进行调整（BMI-sds）。肥胖组的龋齿数（DS）更高，为 0.7 比 0.1（P=0.008），刺激全唾液流速 1.2 比 2.0ml/min 更低（P<0.001）。肥胖患者中，17 例 VPI%>25，21 例 BOP%>25，而正常体重组仅 5 例，P 值分别为 0.005 和<0.001。在多变量逻辑回归模型中，BMI-sds 与刺激全唾液流速低于中位数 1.5ml/min（P<0.001；比值比（OR）1.36）以及 DS（DS>0）（P=0.002；OR 1.31）显著相关，且这些关联未被任何研究变量混淆。结果表明，儿童肥胖与刺激全唾液流速降低和龋齿有关，进一步加强了肥胖对儿童口腔健康的负面影响。
