Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, 210009, People's Republic of China.
Mol Biol Rep. 2011 Jan;38(1):355-8. doi: 10.1007/s11033-010-0115-1. Epub 2010 Mar 26.
MicroRNAs (miRNAs) are a kind of endogenous non-coding small RNAs whose specific functions in animals are generally important. Although functions of some miRNAs have been identified, the role of miR-184 remains unknown. Here, we determined the temporal and spatial expression pattern of miR-184 during the different development stages and tissues in Drosophila. Strikingly, miR-184 is expressed ubiquitously in Drosophila embryos, larvae and adults, its expression pattern shows a dynamic changes during the development of embryo, especially in the central nervous system. This expression profile suggests that miR-184 may act important function in Drosophila development.
微小 RNA（miRNAs）是一类内源性非编码小 RNA，其在动物中的特定功能通常很重要。尽管已经确定了一些 miRNAs 的功能，但 miR-184 的作用仍不清楚。在这里，我们确定了 miR-184 在果蝇不同发育阶段和组织中的时空表达模式。引人注目的是，miR-184 在果蝇胚胎、幼虫和成虫中广泛表达，其表达模式在胚胎发育过程中呈动态变化，特别是在中枢神经系统中。这种表达谱表明，miR-184 可能在果蝇发育中发挥重要作用。
