The Department of Diagnostic Ultrasound, Tianjin Medical University Cancer Institute and Hospital, Huanhuxilu, Tiyuanbei, Hexi District, Tianjin, China.
Med Oncol. 2011 Jun;28(2):429-33. doi: 10.1007/s12032-010-9494-3. Epub 2010 Mar 26.
Large-core needle biopsy (LCNB) is a common diagnostic tool used for breast lesions biopsy under free-hand or ultrasound guidance. In this paper, we have retrospectively studied on 1,431 patients who require histopathological diagnosis of breast lesions by LCNB in Tianjin Cancer Hospital from January 2008 to April 2009. The procedure used automated prone unit, biopsy gun, and 14-gauge or 16-gauge needle under free-hand or ultrasound guidance. The pathological diagnosis and classification (12 features) were independently evaluated by pathologists. The pathological findings showed that 989 (69.1%) was invasive carcinoma, 58 (4.1%) were ductal carcinoma in situ (DCIS), 20 (1.4%) were diagnosed as atypical ductal hyperplasia (ADH), and 124 cases were benign masses. The diagnostic accuracy, sensitivity, and specificity were 0.89, 0.88, and 0.98, respectively. This study suggested that LCNB is a useful histological technique for diagnosing invasive cancer, but may not be inaccurate in diagnosis of ADH and DCIS. For the latter, surgical excision may be necessary.
粗针活检（LCNB）是一种常见的诊断工具，用于在徒手或超声引导下对乳腺病变进行活检。本文回顾性研究了 2008 年 1 月至 2009 年 4 月在天津市肿瘤医院因乳腺病变接受 LCNB 进行组织病理学诊断的 1431 例患者。该方法采用自动俯卧位单元、活检枪和 14 或 16 号针，在徒手或超声引导下进行。病理诊断和分类（12 个特征）由病理学家独立评估。病理结果显示，989 例（69.1%）为浸润性癌，58 例（4.1%）为导管原位癌（DCIS），20 例（1.4%）为非典型导管增生（ADH），124 例为良性肿块。诊断准确率、敏感度和特异度分别为 0.89、0.88 和 0.98。本研究表明，LCNB 是一种用于诊断浸润性癌的有用组织学技术，但对 ADH 和 DCIS 的诊断可能不够准确。对于后者，可能需要手术切除。
