Nikiforova N A, Moskalenko I P, Gaĭseniuk L A, Pozhidaeva O N
Med Radiol (Mosk). 1991;36(5):33-5.
Blood lymphocyte ability for DNA reparation in response to injuring DNA test-exposure of x-radiation in vitro at a dose 250 Gy was investigated in 158 patients with breast and genital tumors and 40 donors. Suppression of the DNA reparative synthesis before a regular course of cancer therapy (which did not depend on a nosological entity, type and number of cancer therapy courses) was noted in 61% of the patients. However the frequency of such patients was significantly increased with regard to tumor spreading. Individual differences in the ability of cancer patients' lymphocytes for reparation before therapy can reflect, to a certain extent, their function and serve as an additional criterion for predicting complications of cancer therapy.
对158例乳腺和生殖系统肿瘤患者及40名献血者进行了研究，检测他们的血液淋巴细胞在体外接受250戈瑞剂量的X射线损伤性DNA检测照射后进行DNA修复的能力。61%的患者在常规癌症治疗疗程之前出现DNA修复合成受抑制的情况（这与疾病分类实体、癌症治疗疗程的类型和次数无关）。然而，随着肿瘤扩散，这类患者的比例显著增加。癌症患者淋巴细胞治疗前修复能力的个体差异在一定程度上可以反映其功能，并可作为预测癌症治疗并发症的附加标准。
