某些抗血吸虫药物的代谢作用——Bilharcid对柠檬酸氧化的抑制作用
Metabolic effects of some antibilharzial drugs inhibition of citrate oxidation by Bilharcid.
作者信息
Sharaf A A, el-Sherbini A, Abdulla W A
出版信息
Egypt J Bilharz. 1976;3(2):247-54.
PMID:203441
Abstract
Bilharcid inhibited citrate oxidation and the inhibition was decreased by time. The inhibition is not restored or reduced by increasing citrate concentration. NAD stimulated citrate oxidation in the presence of Bilharcid. Cysteine slightly stimulated citrate oxidation, while ATP had no effect. Addition of citrate before Bilharcid protected the enzyme against the inhibitory action of the drug.
摘要
双羟萘酸抑制柠檬酸氧化，且这种抑制作用会随时间减弱。增加柠檬酸浓度并不能恢复或减轻这种抑制作用。在双羟萘酸存在的情况下，烟酰胺腺嘌呤二核苷酸（NAD）能刺激柠檬酸氧化。半胱氨酸对柠檬酸氧化有轻微刺激作用，而三磷酸腺苷（ATP）则无影响。在加入双羟萘酸之前添加柠檬酸可保护该酶免受药物的抑制作用。
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