某些抗血吸虫药的代谢作用：比哈西啶对大鼠肝脏中与NAD相关的底物氧化的抑制作用。
Metabolic effects of some antibilharzial drugs: inhibition of NAD-linked substrate oxidation in rat liver by bilharcid.
作者信息
Sharaf A A, el-Sherbini A, Abdulla W A
出版信息
Egypt J Bilharz. 1978;4(1):27-34.
PMID:206427
Abstract
BILHARCID inhibited malate and pyruvate oxidation. The degree of inhibition reached 50% when the concentration of Bilharcid was 10(-3) M. The mechanisms of the inhibitory action of the drug are discussed with reference to the effects of both adenine and pyridine nucleotides on the activity of the oxidoreductase enzymes.
摘要
比哈西得抑制苹果酸和丙酮酸的氧化。当比哈西得浓度为10⁻³ M时，抑制程度达到50%。参照腺嘌呤和吡啶核苷酸对氧化还原酶活性的影响，讨论了该药抑制作用的机制。
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