Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China.
J Org Chem. 2010 May 7;75(9):2966-70. doi: 10.1021/jo100247a.
DMF (N,N-dimethylformamide)/KOH was found to be an efficient hydrogen source in the Pd(OAc)(2)-catalyzed transfer semihydrogenation of various functionalized internal alkynes to afford cis-alkenes in good to high yields with excellent chemo- and stereoselectivity. This catalytic process was also applied to the synthesis of analogues of combretastatin A-4.
DMF（N，N-二甲基甲酰胺）/KOH 被发现是 Pd(OAc)(2)催化的各种官能化内部炔烃转移半氢化反应中有效的氢源，以高产率和优异的化学和立体选择性得到顺式烯烃。该催化过程也被应用于康普瑞汀 A-4 类似物的合成。
