高化学选择性和立体选择性的钯催化内炔烃转移顺式氢化反应得到顺式烯烃。
Highly chemo- and stereoselective palladium-catalyzed transfer semihydrogenation of internal alkynes affording cis-alkenes.
机构信息
Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China.
出版信息
J Org Chem. 2010 May 7;75(9):2966-70. doi: 10.1021/jo100247a.
PMID:20345142
Abstract
DMF (N,N-dimethylformamide)/KOH was found to be an efficient hydrogen source in the Pd(OAc)(2)-catalyzed transfer semihydrogenation of various functionalized internal alkynes to afford cis-alkenes in good to high yields with excellent chemo- and stereoselectivity. This catalytic process was also applied to the synthesis of analogues of combretastatin A-4.
摘要
DMF（N，N-二甲基甲酰胺）/KOH 被发现是 Pd(OAc)(2)催化的各种官能化内部炔烃转移半氢化反应中有效的氢源，以高产率和优异的化学和立体选择性得到顺式烯烃。该催化过程也被应用于康普瑞汀 A-4 类似物的合成。
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