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在普通人群中，主动脉18F-FDG摄取与低密度脂蛋白胆固醇和瘦素相关。

Uptake of aortic 18F-FDG is correlated with low-density lipoprotein cholesterol and leptin in a general population.

作者信息

Haraguchi Ai, Hayashida Naomi, Kamasaki Toshihiko, Miyamoto Izumi, Usui Toshiya, Ando Takao, Abiru Norio, Yamasaki Hironori, Chiba Kenya, Kudo Takashi, Kawakami Atsushi, Takamura Noboru

机构信息

Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

出版信息

PLoS One. 2014 Nov 6;9(11):e111990. doi: 10.1371/journal.pone.0111990. eCollection 2014.

DOI:10.1371/journal.pone.0111990
PMID:25375161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4222970/
Abstract

OBJECTIVE

This study investigated the relationship between aortic 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and clinical and laboratory findings related to atherosclerosis in a general population.

METHODS

18F-FDG uptake in the ascending aorta was measured on the positron emission tomography/computed tomography (PET/CT) scans of 211 Japanese adults. The maximum target-to-background ratio (TBR) was compared with clinical and laboratory atherosclerosis findings.

RESULTS

By multivariate regression analysis adjusted for age and sex, TBR-ascending aorta (TBR-A) was significantly correlated with various clinical and laboratory parameters, such as body mass index, log visceral fat area, low-density lipoprotein cholesterol (LDL-C), log fasting immunoreactive insulin, log homeostasis model assessment of insulin resistance, log total adiponectin and log-leptin, in all subjects. Furthermore, by multivariate linear regression analysis adjusted for confounding factors, TBR-A was significantly correlated with LDL-C (β = 0.001, p = 0.03) and log-leptin (β = 0.336, p<0.01) in all subjects.

CONCLUSION

TBR-A was significantly correlated with LDL-C and log-leptin independent from confounding factors. Our results suggest that aortic 18F-FDG uptake is a good marker of atherosclerosis, even in a general population.

摘要

目的

本研究调查了普通人群中主动脉18F-氟-2-脱氧-D-葡萄糖（18F-FDG）摄取与动脉粥样硬化相关的临床及实验室检查结果之间的关系。

方法

对211名日本成年人的正电子发射断层扫描/计算机断层扫描（PET/CT）图像进行分析，测量升主动脉的18F-FDG摄取情况。将最大靶本比（TBR）与临床及实验室动脉粥样硬化检查结果进行比较。

结果

在对年龄和性别进行校正的多因素回归分析中，升主动脉TBR（TBR-A）与所有受试者的多种临床及实验室参数显著相关，如体重指数、内脏脂肪面积对数、低密度脂蛋白胆固醇（LDL-C）、空腹免疫反应性胰岛素对数、胰岛素抵抗稳态模型评估对数、总脂联素对数以及瘦素对数。此外，在对混杂因素进行校正的多因素线性回归分析中，TBR-A与所有受试者的LDL-C（β = 0.001，p = 0.03）和瘦素对数（β = 0.336，p<0.01）显著相关。

结论

TBR-A与LDL-C和瘦素对数显著相关，且不受混杂因素影响。我们的结果表明，即使在普通人群中，主动脉18F-FDG摄取也是动脉粥样硬化的良好标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/4222970/8b751f8119e9/pone.0111990.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/4222970/8b751f8119e9/pone.0111990.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa31/4222970/8b751f8119e9/pone.0111990.g001.jpg

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