Takamura Noboru, Akilzhanova Ainur, Hayashida Naomi, Kadota Koichiro, Yamasaki Hironori, Usa Toshiro, Nakazato Mio, Maeda Takahiro, Ozono Yoshiyuki, Aoyagi Kiyoshi
Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 8528523, Japan.
Atherosclerosis. 2009 Jun;204(2):e77-81. doi: 10.1016/j.atherosclerosis.2008.09.022. Epub 2008 Sep 27.
To investigate the relationship between thyroid function and carotid intima-media thickness (CIMT) in a relatively large general population with euthyroid status we initially enrolled 1772 Japanese adults (421 men and 1351 women) who participated in a medical screening program for the general population over 40 years old. To evaluate only euthyroid subjects without vascular diseases and/or its major risk factors, 1129 were excluded and 643 participants (175 men and 468 women) were included for further analysis. Simple and multivariate linear regression analyses were performed to evaluate free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels and other existing parameters, including carotid intima-media thickness. By multivariate linear regression analysis adjusted for age and sex, free thyroxine was significantly correlated with triglycerides (beta=0.07, p=0.015), carotid intima-media thickness (beta=-0.091, p=0.049), and thyroid-stimulating hormone (beta=-0.091, p=0.003). Thyroid-stimulating hormone was significantly correlated with high-density lipoprotein cholesterol (HDL-C) (beta=-0.001, p=0.015), HbA(1c) (beta=0.038, p=0.045), carotid intima-media thickness (beta=0.27, p=0.001), and free thyroxine (beta=-0.15, p=0.003). When adjusted for confounding factors, free thyroxine was significantly correlated only with carotid intima-media thickness (beta=-0.13, p=0.043) and thyroid-stimulating hormone was significantly correlated with HDL-C (beta=-0.001, p<0.001), HbA(1c) (beta=0.04, p=0.021), and carotid intima-media thickness (beta=0.29, p=0.001). We have demonstrated that carotid intima-media thickness is independently associated with thyroid function within the normal reference range, which suggests an increased cardiovascular risk in subjects with low normal thyroid function.
为了在甲状腺功能正常的相对较大规模的普通人群中研究甲状腺功能与颈动脉内膜中层厚度（CIMT）之间的关系，我们最初招募了1772名日本成年人（421名男性和1351名女性），他们参加了针对40岁以上普通人群的医疗筛查项目。为了仅评估无血管疾病和/或其主要危险因素的甲状腺功能正常的受试者，排除了1129人，纳入643名参与者（175名男性和468名女性）进行进一步分析。进行了简单和多元线性回归分析，以评估游离甲状腺素（fT4）、促甲状腺激素（TSH）水平及其他现有参数，包括颈动脉内膜中层厚度。经年龄和性别校正的多元线性回归分析显示，游离甲状腺素与甘油三酯（β = 0.07，p = 0.015）、颈动脉内膜中层厚度（β = -0.091，p = 0.049）和促甲状腺激素（β = -0.091，p = 0.003）显著相关。促甲状腺激素与高密度脂蛋白胆固醇（HDL-C）（β = -0.001，p = 0.015）、糖化血红蛋白（HbA1c）（β = 0.038，p = 0.045）、颈动脉内膜中层厚度（β = 0.27，p = 0.001）和游离甲状腺素（β = -0.15，p = 0.003）显著相关。校正混杂因素后，游离甲状腺素仅与颈动脉内膜中层厚度显著相关（β = -0.13，p = 0.043），促甲状腺激素与HDL-C（β = -0.001，p < 0.001）、HbA1c（β = 0.04，p = 0.021）和颈动脉内膜中层厚度（β = 0.29，p = 0.001）显著相关。我们已经证明，在正常参考范围内，颈动脉内膜中层厚度与甲状腺功能独立相关，这表明甲状腺功能略低于正常水平的受试者心血管风险增加。
