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综述:阿尔茨海默病患者淡漠的诊断、评估与治疗。

REVIEW: Apathy diagnosis, assessment, and treatment in Alzheimer's disease.

机构信息

Centre Mémoire de Ressources et de Recherche, CHU de Nice, Université de Nice-Sophia Antipolis, France.

出版信息

CNS Neurosci Ther. 2010 Oct;16(5):263-71. doi: 10.1111/j.1755-5949.2009.00132.x.

DOI:10.1111/j.1755-5949.2009.00132.x
PMID:20345973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6493869/
Abstract

Apathy is defined as a disorder of motivation. There is wide acknowledgement that apathy is an important behavioral syndrome in Alzheimer's disease and in various neuropsychiatric disorders. In light of recent research and the renewed interest in the correlates and impacts of apathy and in its treatments, it is important to develop criteria for apathy that will be widely accepted, have clear operational steps, and be easy to apply in clinical practice and in research settings. Meeting these needs was the focus for a task force that included members of the European Psychiatric Association, the European Alzheimer's Disease Consortium and experts from Europe, Australia and North America.

摘要

冷漠定义为一种动机障碍。人们普遍承认,冷漠是阿尔茨海默病和各种神经精神疾病中的重要行为综合征。鉴于最近的研究以及对冷漠的相关性、影响及其治疗的重新关注,制定广泛接受、具有明确操作步骤且易于在临床实践和研究环境中应用的冷漠标准非常重要。满足这些需求是一个工作组的重点,该工作组包括欧洲精神病学协会、欧洲阿尔茨海默病联合会以及来自欧洲、澳大利亚和北美的专家的成员。

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本文引用的文献

1
Pharmacological treatment of apathy in neurodegenerative diseases: a systematic review.神经退行性疾病中淡漠症状的药物治疗:一项系统综述
Dement Geriatr Cogn Disord. 2009;28(1):13-22. doi: 10.1159/000228840. Epub 2009 Jul 17.
2
Donepezil delays progression to AD in MCI subjects with depressive symptoms.多奈哌齐可延缓伴有抑郁症状的轻度认知障碍(MCI)患者向阿尔茨海默病(AD)的进展。
Neurology. 2009 Jun 16;72(24):2115-21. doi: 10.1212/WNL.0b013e3181aa52d3.
3
Dopamine modulates cholinergic cortical excitability in Alzheimer's disease patients.多巴胺调节阿尔茨海默病患者的胆碱能皮质兴奋性。
Neuropsychopharmacology. 2009 Sep;34(10):2323-8. doi: 10.1038/npp.2009.60. Epub 2009 Jun 10.
4
Differential impact of apathy and depression in the development of dementia in mild cognitive impairment patients.冷漠和抑郁对轻度认知障碍患者痴呆症发展的不同影响。
Dement Geriatr Cogn Disord. 2009;27(4):390-8. doi: 10.1159/000210045. Epub 2009 Apr 1.
5
Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders.阿尔茨海默病及其他神经精神障碍中淡漠的拟诊标准。
Eur Psychiatry. 2009 Mar;24(2):98-104. doi: 10.1016/j.eurpsy.2008.09.001. Epub 2009 Feb 7.
6
Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease.胆碱能对阿尔茨海默病患者大脑对西酞普兰代谢反应的调节作用
Brain. 2009 Feb;132(Pt 2):392-401. doi: 10.1093/brain/awn326. Epub 2009 Jan 19.
7
Antidepressants and dementia.抗抑郁药与痴呆。
J Affect Disord. 2009 Sep;117(1-2):24-9. doi: 10.1016/j.jad.2008.11.020. Epub 2009 Jan 12.
8
Persistent apathy in Alzheimer's disease as an independent factor of rapid functional decline: the REAL longitudinal cohort study.阿尔茨海默病患者持续性淡漠是快速功能衰退的独立因素:REAL 纵向队列研究。
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9
Importance of lack of interest in patients with mild cognitive impairment.轻度认知障碍患者兴趣缺乏的重要性。
Am J Geriatr Psychiatry. 2008 Sep;16(9):770-6. doi: 10.1097/JGP.0b013e31817e73db.
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Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease.阿尔茨海默病神经精神症状的神经解剖学关联
Brain. 2008 Sep;131(Pt 9):2455-63. doi: 10.1093/brain/awn151. Epub 2008 Jul 11.