Robert Philippe H, Berr Claudine, Volteau Magali, Bertogliati-Fileau Christelle, Benoit Michel, Guerin Olivier, Sarazin Marie, Legrain Sylvie, Dubois Bruno
Centre Mémoire de Ressources et de Recherche, CHU de Nice, INSERM JE 2441, Nice, France.
Am J Geriatr Psychiatry. 2008 Sep;16(9):770-6. doi: 10.1097/JGP.0b013e31817e73db.
Apathy is one of the most common behavioral symptoms in mild cognitive impairment (MCI). The aim of the authors' study was to examine the influence of the apathy dimensions, i.e., emotional blunting, lack of initiative, and lack of interest, on the risk of developing of Alzheimer disease (AD) in patients with MCI.
Longitudinal study.
Fourteen French memory clinics.
Apathy was assessed in 214 MCI patients. The main endpoint considered was the development of AD during the 3-year follow-up.
The neuropsychiatric evaluation included the Goldberg anxiety scale and the Montgomery and Asberg Depression Rating Scale; apathy was assessed with the Apathy Inventory.
After 3 years, 59 patients (27.2%) had developed AD. The risk of conversion to AD was significantly higher for patients with lack of interest. Using Cox analyses, controlling for age, gender and education, the difference between survival curves was significant for lack of interest.
Lack of interest, a mild behavioral sign, could be an indicator of potential decline in MCI patients and underlines the importance of checking the cognitive status of these patients.
冷漠是轻度认知障碍（MCI）最常见的行为症状之一。作者研究的目的是探讨冷漠的维度，即情感迟钝、缺乏主动性和缺乏兴趣，对MCI患者患阿尔茨海默病（AD）风险的影响。
纵向研究。
14家法国记忆诊所。
对214例MCI患者进行了冷漠评估。主要终点是3年随访期间AD的发生情况。
神经精神评估包括戈德堡焦虑量表和蒙哥马利-阿斯伯格抑郁评定量表；使用冷漠量表评估冷漠情况。
3年后，59例患者（27.2%）患了AD。缺乏兴趣的患者转化为AD的风险显著更高。使用Cox分析，在控制年龄、性别和教育程度后，缺乏兴趣的患者生存曲线差异显著。
缺乏兴趣这一轻微行为迹象可能是MCI患者潜在衰退的指标，并强调了检查这些患者认知状态的重要性。
