伏隔核中μ阿片受体激活诱导的高脂肪摄入被 Y1R 阻断和 MC3/4R 刺激所抑制。
High-fat intake induced by mu-opioid activation of the nucleus accumbens is inhibited by Y1R-blockade and MC3/4R- stimulation.
机构信息
Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.
出版信息
Brain Res. 2010 Sep 2;1350:131-8. doi: 10.1016/j.brainres.2010.03.061. Epub 2010 Mar 24.
Abstract
Nucleus accumbens mu-opioid receptor activation can strongly stimulate intake of high-fat food in satiated rats, and one of the mechanisms involves activation of lateral hypothalamic orexin neurons and orexin receptor-1 signaling in the mesolimbic dopamine system. Here, we tested the potential contribution of NPY/Y1R and alpha-MSH/MC3/4R-signaling to accumbens-induced high-fat feeding. Prior administration of the selective Y1R antagonist 1229U91 or the MC3/4R agonist MTII into the lateral ventricle (LV) dose-dependently decreased high-fat intake induced by nucleus accumbens injection of the mu-opioid receptor agonist DAMGO. Both drugs also decreased high-fat feeding induced by switching rats from regular chow to high-fat diet, but less efficiently than when DAMGO-induced. Administration of 1229U91 directly into the PVH also suppressed DAMGO-induced high-fat intake, but a higher dose was required. The results suggest that NPY/Y1R signaling in the PVH and other forebrain sites is necessary for accumbens DAMGO to elicit high-fat intake, and that forebrain MC3/4R signaling can suppress it.
摘要
伏隔核 μ 阿片受体的激活可以强烈刺激饱食大鼠摄入高脂肪食物，其机制之一涉及外侧下丘脑食欲素神经元的激活和中脑边缘多巴胺系统中食欲素受体-1 信号传导。在这里，我们测试了 NPY/Y1R 和 α-MSH/MC3/4R 信号传导对伏隔核诱导的高脂肪进食的潜在贡献。选择性 Y1R 拮抗剂 1229U91 或 MC3/4R 激动剂 MTII 预先给药到侧脑室（LV）可剂量依赖性地降低由伏隔核注射 μ 阿片受体激动剂 DAMGO 诱导的高脂肪摄入。这两种药物也降低了大鼠从常规饲料转换为高脂肪饮食时的高脂肪进食，但效果不如 DAMGO 诱导的那么好。1229U91 直接给药到 PVH 也抑制了 DAMGO 诱导的高脂肪摄入，但需要更高的剂量。结果表明，PVH 和其他前脑部位的 NPY/Y1R 信号传导对于伏隔核 DAMGO 引发高脂肪摄入是必要的，并且前脑 MC3/4R 信号传导可以抑制它。
相似文献
1
High-fat intake induced by mu-opioid activation of the nucleus accumbens is inhibited by Y1R-blockade and MC3/4R- stimulation.伏隔核中μ阿片受体激活诱导的高脂肪摄入被 Y1R 阻断和 MC3/4R 刺激所抑制。
Brain Res. 2010 Sep 2;1350:131-8. doi: 10.1016/j.brainres.2010.03.061. Epub 2010 Mar 24.
2
CB1 receptors modulate the intake of a sweetened-fat diet in response to μ-opioid receptor stimulation of the nucleus accumbens.大麻素 1 型受体通过调节伏隔核中μ-阿片受体对加糖脂肪饮食摄入的反应。
Pharmacol Biochem Behav. 2010 Nov;97(1):144-51. doi: 10.1016/j.pbb.2010.05.024. Epub 2010 Jun 1.
3
Amygdalar opioids modulate hypothalamic melanocortin-induced anorexia.杏仁核阿片类物质调节下丘脑促黑素诱导的厌食症。
Physiol Behav. 2009 Mar 23;96(4-5):568-73. doi: 10.1016/j.physbeh.2008.12.007. Epub 2008 Dec 24.
4
Excitatory amino acid receptor subtype agonists induce feeding in the nucleus accumbens shell in rats: opioid antagonist actions and interactions with mu-opioid agonists.兴奋性氨基酸受体亚型激动剂可诱导大鼠伏隔核壳部摄食：阿片类拮抗剂的作用以及与μ-阿片类激动剂的相互作用。
Brain Res. 2001 Dec 7;921(1-2):86-97. doi: 10.1016/s0006-8993(01)03094-3.
5
Central amygdala opioid transmission is necessary for increased high-fat intake following 24-h food deprivation, but not following intra-accumbens opioid administration.中枢杏仁核阿片类物质传递对于24小时食物剥夺后高脂摄入量增加是必要的，但在伏隔核内给予阿片类药物后则不然。
Behav Brain Res. 2014 Mar 1;260:131-8. doi: 10.1016/j.bbr.2013.11.014. Epub 2013 Nov 17.
6
The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.伏隔核腺苷-阿片相互作用在介导美味食物摄入中的作用。
Brain Res. 2010 Jan 8;1306:85-92. doi: 10.1016/j.brainres.2009.09.115. Epub 2009 Oct 12.
7
gamma-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats.γ-氨基丁酸受体亚型拮抗剂对大鼠伏隔核壳区阿片类物质诱导的摄食有不同影响。
Brain Res. 2001 Jul 6;906(1-2):84-91. doi: 10.1016/s0006-8993(01)02558-6.
8
Alterations in food intake by opioid and dopamine signaling pathways between the ventral tegmental area and the shell of the nucleus accumbens.腹侧被盖区与伏隔核壳之间的阿片类和多巴胺信号通路对食物摄入量的影响。
Brain Res. 2004 Aug 20;1018(1):78-85. doi: 10.1016/j.brainres.2004.05.043.
9
Mu-opioid stimulation in rat prefrontal cortex engages hypothalamic orexin/hypocretin-containing neurons, and reveals dissociable roles of nucleus accumbens and hypothalamus in cortically driven feeding.大鼠前额皮质中 μ-阿片受体刺激会激活下丘脑含有食欲素/下丘脑分泌素的神经元，并揭示了伏隔核和下丘脑在皮质驱动进食中的可分离作用。
J Neurosci. 2013 Nov 20;33(47):18540-52. doi: 10.1523/JNEUROSCI.3323-12.2013.
10
Amylin receptor signaling in the nucleus accumbens negatively modulates μ-opioid-driven feeding.伏隔核中的胰岛淀粉样多肽受体信号传导对μ-阿片类药物驱动的进食产生负调节作用。
Neuropsychopharmacology. 2014 Dec;39(13):3009-17. doi: 10.1038/npp.2014.153. Epub 2014 Jun 24.
引用本文的文献
1
Homeostatic-related peptides injected into the rat nucleus accumbens alter palatable eating and impact the binge-like intake of a sweetened fat diet during simultaneous μ-opioid receptor stimulation.注射到大鼠伏隔核的内稳态相关肽会改变美味饮食，并在同时进行μ-阿片受体刺激时影响高脂高糖饮食的暴饮暴食。
Front Neurosci. 2025 Jul 14;19:1614819. doi: 10.3389/fnins.2025.1614819. eCollection 2025.
2
Integration of Endogenous Opioid System Research in the Interprofessional Diagnosis and Treatment of Obesity and Eating Disorders.内源性阿片系统研究在肥胖和饮食障碍的跨专业诊断和治疗中的整合。
Adv Neurobiol. 2024;35:357-380. doi: 10.1007/978-3-031-45493-6_18.
3
Role of Endogenous Opioids in the Pathophysiology of Obesity and Eating Disorders.内源性阿片在肥胖和饮食失调的病理生理学中的作用。
Adv Neurobiol. 2024;35:329-356. doi: 10.1007/978-3-031-45493-6_17.
4
Proopiomelanocortin projections to the nucleus accumbens modulate acquisition and maintenance of operant palatable pellet administration in mice.阿黑皮素原向前脑垂体核投射调节小鼠操作性美味丸给药的获得和维持。
Physiol Behav. 2023 Jun 1;265:114176. doi: 10.1016/j.physbeh.2023.114176. Epub 2023 Mar 23.
5
Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.向伏隔核微量注射黑皮质素受体激动剂二型促黑素，可减少对食物的食欲和摄食反应。
Neuropeptides. 2022 Dec;96:102289. doi: 10.1016/j.npep.2022.102289. Epub 2022 Sep 16.
6
Structural basis of neuropeptide Y signaling through Y1 receptor.神经肽Y通过Y1受体信号传导的结构基础。
Nat Commun. 2022 Feb 14;13(1):853. doi: 10.1038/s41467-022-28510-6.
7
Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli.Y1 受体调节雄性小鼠对典型味觉刺激的味觉相关行为反应。
Horm Behav. 2021 Nov;136:105056. doi: 10.1016/j.yhbeh.2021.105056. Epub 2021 Sep 9.
8
Physiologic and Neural Controls of Eating.饮食的生理和神经控制
Gastroenterol Clin North Am. 2016 Dec;45(4):581-599. doi: 10.1016/j.gtc.2016.07.009. Epub 2016 Oct 13.
9
Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.中脑多巴胺神经元中的黑皮质素3受体信号增强了对食物奖励的动机。
Neuropsychopharmacology. 2016 Aug;41(9):2241-51. doi: 10.1038/npp.2016.19. Epub 2016 Feb 8.
10
Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity.伏隔核中的神经肽Y活性调节进食行为和神经元活动。
Biol Psychiatry. 2015 Apr 1;77(7):633-41. doi: 10.1016/j.biopsych.2014.06.008. Epub 2014 Jun 18.
本文引用的文献
1
Chronic suppression of μ-opioid receptor signaling in the nucleus accumbens attenuates development of diet-induced obesity in rats.伏隔核中 μ 阿片受体信号的慢性抑制可减轻大鼠饮食诱导肥胖的发展。
Int J Obes (Lond). 2010 Jun;34(6):1001-10. doi: 10.1038/ijo.2009.297. Epub 2010 Jan 12.
2
The role of hypocretin in driving arousal and goal-oriented behaviors.食欲素在驱动觉醒和目标导向行为中的作用。
Brain Res. 2010 Feb 16;1314:103-11. doi: 10.1016/j.brainres.2009.11.054. Epub 2009 Nov 27.
3
The hypocretins as sensors for metabolism and arousal.下丘脑泌素作为代谢和觉醒的传感器。
J Physiol. 2009 Jan 15;587(1):33-40. doi: 10.1113/jphysiol.2008.164400. Epub 2008 Dec 1.
4
Opioid reward 'liking' and 'wanting' in the nucleus accumbens.伏隔核中的阿片类奖赏“喜好”与“渴望”
Physiol Behav. 2008 Aug 6;94(5):675-80. doi: 10.1016/j.physbeh.2008.04.006. Epub 2008 Apr 13.
5
Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens.伏隔核的阿片类物质刺激所诱导的高脂食欲需要腹侧被盖区的食欲素信号传导。
J Neurosci. 2007 Oct 10;27(41):11075-82. doi: 10.1523/JNEUROSCI.3542-07.2007.
6
Striatal medium spiny neurons terminate in a distinct region in the lateral hypothalamic area and do not directly innervate orexin/hypocretin- or melanin-concentrating hormone-containing neurons.纹状体中等棘状神经元在外侧下丘脑区域的一个独特区域终止，并不直接支配含食欲素/下丘脑泌素或促黑素细胞激素的神经元。
J Neurosci. 2007 Jun 27;27(26):6948-55. doi: 10.1523/JNEUROSCI.0514-07.2007.
7
Nucleus accumbens opioid signaling conditions short-term flavor preferences.伏隔核阿片类信号传导决定短期口味偏好。
Neuroscience. 2007 Apr 25;146(1):19-30. doi: 10.1016/j.neuroscience.2007.01.005. Epub 2007 Feb 21.
8
Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding.可区分动机过程的离散神经化学编码：来自伏隔核控制进食的见解。
Psychopharmacology (Berl). 2007 Apr;191(3):439-59. doi: 10.1007/s00213-007-0741-z. Epub 2007 Feb 23.
9
Interactions between the "cognitive" and "metabolic" brain in the control of food intake.在食物摄入控制中“认知”与“代谢”大脑之间的相互作用。
Physiol Behav. 2007 Aug 15;91(5):486-98. doi: 10.1016/j.physbeh.2006.12.016. Epub 2007 Jan 12.
10
Nucleus accumbens opioids regulate flavor-based preferences in food consumption.伏隔核阿片类物质调节食物消费中基于味道的偏好。
Neuroscience. 2006 Nov 17;143(1):309-17. doi: 10.1016/j.neuroscience.2006.06.067.
Zotero 插件