Psychology Department, Queens College, City University of New York, Flushing, NY 11367, United States.
Behav Brain Res. 2010 Aug 25;211(2):141-7. doi: 10.1016/j.bbr.2010.03.029. Epub 2010 Mar 25.
New neurons formed in the adult brain are incorporated into existing circuits. However, the number of new neurons recruited into a given brain region varies widely depending on the experience of the animal. An emerging general principle is that recruitment and early neuronal survival may be correlated with activity or use of the brain region. Here we show that use-dependent neuronal survival also occurs in the higher order auditory processing region of the songbird caudomedial nidopallium (NCM). We suggest that retention of young neurons may in part be influenced by use of the system without an increased demand for learning or behavioral plasticity.
成年大脑中形成的新神经元会融入现有的回路中。然而，新神经元在特定脑区的募集数量会因动物的经历而有很大的不同。一个新出现的普遍原则是，募集和早期神经元存活可能与脑区的活动或使用有关。在这里，我们表明，依赖于使用的神经元存活也发生在鸣禽的后顶区（NCM）的高级听觉处理区。我们认为，年轻神经元的保留可能部分受到系统使用的影响，而不需要增加学习或行为可塑性的需求。
