Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
J Reprod Immunol. 2010 May;85(1):58-62. doi: 10.1016/j.jri.2010.01.005. Epub 2010 Mar 29.
Self and non-self recognition is the key mechanism by which the immune system determines whether or not to mount an immune response. During pregnancy the maternal immune system must tolerate the persistence of non-self semi-allogeneic fetal cells in the maternal tissue. Although many mechanisms have been shown to contribute to the prevention of a destructive maternal immune response to fetal cells, the immune acceptance of the allogeneic fetus in pregnancy largely remains an immunological paradox (Billingham et al., 1953). The aim of this review is to describe the expression of the polymorphic histocompatibility antigens at the fetal-maternal interface, their interaction with maternal leukocytes and their possible roles in immune regulation at the fetal-maternal interface during human pregnancy.
自身与非自身识别是免疫系统决定是否产生免疫应答的关键机制。在妊娠期间，母体免疫系统必须耐受非自身半同种胎儿细胞在母体组织中的持续存在。尽管已经证明许多机制有助于防止母体对胎儿细胞产生破坏性免疫应答，但妊娠期间同种异体胎儿的免疫接受在很大程度上仍然是一个免疫学悖论（Billingham 等人，1953 年）。本综述的目的是描述在人类妊娠期间胎儿-母体界面上多态性组织相容性抗原的表达、它们与母体白细胞的相互作用及其在胎儿-母体界面免疫调节中的可能作用。
