Munhoz Renato P, Werneck Lineu C, Teive Hélio A G
Movement Disorders Unit, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.
Clin Neurol Neurosurg. 2010 Jun;112(5):431-5. doi: 10.1016/j.clineuro.2010.03.003. Epub 2010 Mar 27.
To investigate the etiologic diagnoses of parkinsonism, underlining aspects of each form and comparing our findings with those published in a similar setting, 10 years before.
A large cohort of 1528 patients with parkinsonism was analyzed, gathering data on demography, motor and non-motor characteristics, as well as the final etiologic diagnoses based on established criteria.
Parkinson's disease (PD) was the most common diagnosis representing 74.7%, followed by drug-induced parkinsonism (DIP) in 7.9%, vascular parkinsonism (VP) in 3.9%, other neurodegenerative disorders in 10%, and rare sporadic causes, divided as genetic, infectious and others, that summed 3.5%. Comparative analysis of these groups showed that each has particularities that extend beyond their diagnostic criteria.
The main conclusions are that the most important causes of parkinsonism in this setting are typical, with PD been the most common diagnosis, although other causes were frequent, encompassing one fourth of all cases. Although DIP was identified in a particularly large part of this cohort, this proportion is smaller than demonstrated previously in a Brazilian study conducted in the 90s. This decrease probably reflects higher awareness regarding the risk of this motor complication and the more widely used newer antipsychotics.
调查帕金森综合征的病因诊断，强调每种类型的特点，并将我们的研究结果与10年前在类似情况下发表的结果进行比较。
分析了一大群1528例帕金森综合征患者，收集了有关人口统计学、运动和非运动特征的数据，以及基于既定标准的最终病因诊断。
帕金森病（PD）是最常见的诊断，占74.7%，其次是药物性帕金森综合征（DIP），占7.9%，血管性帕金森综合征（VP），占3.9%，其他神经退行性疾病，占10%，以及罕见的散发性病因，分为遗传、感染和其他，总计占3.5%。对这些组的比较分析表明，每组都有超出其诊断标准的特殊性。
主要结论是，在这种情况下，帕金森综合征的最重要病因是典型的，PD是最常见的诊断，尽管其他病因也很常见，占所有病例的四分之一。尽管在该队列的很大一部分中发现了DIP，但这一比例低于90年代在巴西进行的一项研究中所显示的比例。这种下降可能反映了对这种运动并发症风险的更高认识以及更新型抗精神病药物的更广泛使用。
Zotero 插件