Ma Kai, Xiong Nian, Shen Yan, Han Chao, Liu Ling, Zhang Guoxin, Wang Luxi, Guo Shiyi, Guo Xingfang, Xia Yun, Wan Fang, Huang Jinsha, Lin Zhicheng, Wang Tao
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Neurology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Front Aging Neurosci. 2018 Jan 19;10:1. doi: 10.3389/fnagi.2018.00001. eCollection 2018.
Parkinson's Disease (PD) is currently considered a systemic neurodegenerative disease manifested with not only motor but also non-motor symptoms. In particular, weight loss and malnutrition, a set of frequently neglected non-motor symptoms, are indeed negatively associated with the life quality of PD patients. Moreover, comorbidity of weight loss and malnutrition may impact disease progression, giving rise to dyskinesia, cognitive decline and orthostatic hypotension, and even resulting in disability and mortality. Nevertheless, the underlying mechanism of weight loss and malnutrition in PD remains obscure and possibly involving multitudinous, exogenous or endogenous, factors. What is more, there still does not exist any weight loss and malnutrition appraision standards and management strategies. Given this, here in this review, we elaborate the weight loss and malnutrition study status in PD and summarize potential determinants and mechanisms as well. In conclusion, we present current knowledge and future prospects of weight loss and malnutrition in the context of PD, aiming to appeal clinicians and researchers to pay a closer attention to this phenomena and enable better management and therapeutic strategies in future clinical practice.
帕金森病（PD）目前被认为是一种全身性神经退行性疾病，不仅表现为运动症状，还表现为非运动症状。特别是，体重减轻和营养不良这一组经常被忽视的非运动症状，确实与PD患者的生活质量呈负相关。此外，体重减轻和营养不良的合并症可能会影响疾病进展，导致运动障碍、认知衰退和体位性低血压，甚至导致残疾和死亡。然而，PD患者体重减轻和营养不良的潜在机制仍然不清楚，可能涉及众多外源性或内源性因素。更重要的是，目前仍然不存在任何体重减轻和营养不良的评估标准及管理策略。鉴于此，在本综述中，我们阐述了PD患者体重减轻和营养不良的研究现状，并总结了潜在的决定因素和机制。总之，我们介绍了PD背景下体重减轻和营养不良的当前知识和未来前景，旨在呼吁临床医生和研究人员更加关注这一现象，并在未来临床实践中制定更好的管理和治疗策略。
