Department of Surgery, Division of Vascular Surgery, Mount Sinai School of Medicine, New York, NY, USA.
J Vasc Surg. 2010 Jun;51(6):1354-9. doi: 10.1016/j.jvs.2010.01.030. Epub 2010 Mar 29.
Compared to open repair of abdominal aortic aneurysms (AAA), endovascular aneurysm repair (EVAR) is associated with decreased perioperative morbidity and mortality. This study sought to examine the outcomes of EVAR in patients >or=80 years of age.
This was a retrospective review from a prospectively maintained computerized database. A total of 322 patients aged >or=80 underwent elective EVAR from January 1997 to November 2007. Mean age was 84 years +/- 3.4 years (range, 80-95 years), and 78.5% were male. Mean aneurysm size was 62 mm +/- 12 mm (range, 39-110 mm).
Mean procedural blood loss was 350 mL (range, 50-2700 mL), and 13.9% required intraoperative transfusion. Mean length of postoperative stay was 2.46 days (median, 1 day; range, 1-42 days), with 54.3% of patients discharged on the first postoperative day. There were 25 (7.8%) perioperative major adverse events. The most common were categorized as device-related (6), cardiac (4), gastrointestinal (4), and bleeding/hematoma (3). The perioperative 30-day mortality rate was 3.1% (10 of 322). Mean follow-up was 25.7 months (range, 1-110 months). Overall, 47 patients (14.6%) required secondary intervention, 7 patients (2.2%) underwent conversion to open repair, and 4 patients (1.2%) died from AAA rupture. Endoleaks occurred in 95 patients (29.4%), with 20 type I, 48 type II, and 27 of indeterminate type; of these, 10 patients with type I endoleaks underwent secondary intervention. Freedom from all-cause mortality at 1 year was 84.3% and at 5 years was 27.4%. Freedom from aneurysm-related mortality at 5 years was 92.9%.
EVAR in octogenarians is associated with high procedural success and low perioperative morbidity and mortality. The midterm results of this study support the use of EVAR in this patient population. Further studies are needed to predict short-term and long-term mortality risk, and treatment for other causes of death.
与开放修复腹主动脉瘤(AAA)相比,血管内修复术(EVAR)与围手术期发病率和死亡率降低相关。本研究旨在检查 80 岁以上患者 EVAR 的结果。
这是一项从前瞻性维护的计算机数据库中进行的回顾性研究。1997 年 1 月至 2007 年 11 月,共有 322 名年龄 80 岁以上的患者接受了择期 EVAR。平均年龄为 84 岁 +/- 3.4 岁(范围 80-95 岁),78.5%为男性。平均动脉瘤大小为 62 毫米 +/- 12 毫米(范围 39-110 毫米)。
平均手术失血量为 350 毫升(范围 50-2700 毫升),13.9%需要术中输血。平均术后住院时间为 2.46 天(中位数为 1 天;范围 1-42 天),54.3%的患者在术后第一天出院。有 25 例(7.8%)围手术期发生主要不良事件。最常见的分类为器械相关(6)、心脏(4)、胃肠道(4)和出血/血肿(3)。围手术期 30 天死亡率为 3.1%(322 例中有 10 例)。平均随访时间为 25.7 个月(范围 1-110 个月)。总体而言,47 例患者(14.6%)需要二次干预,7 例患者(2.2%)转为开放修复,4 例患者(1.2%)死于 AAA 破裂。95 例患者(29.4%)发生内漏,其中 20 例为 I 型,48 例为 II 型,27 例为不确定型;其中 10 例 I 型内漏患者进行了二次干预。1 年时全因死亡率的无事件生存率为 84.3%,5 年时为 27.4%。5 年时动脉瘤相关死亡率的无事件生存率为 92.9%。
80 岁以上患者行 EVAR 手术成功率高,围手术期发病率和死亡率低。本研究的中期结果支持在该患者人群中使用 EVAR。需要进一步研究以预测短期和长期死亡率风险以及其他死因的治疗。