Bhattad Pradnya Brijmohan, Kulkarni Mugdha, Patel Parasbhai D, Roumia Mazen
Cardiovascular Medicine, Saint Vincent Hospital, UMass Chan Medical School, Worcester, USA.
Internal Medicine, BronxCare Hospital, Bronx, USA.
Cureus. 2022 Jun 3;14(6):e25633. doi: 10.7759/cureus.25633. eCollection 2022 Jun.
Ankylosing spondylitis (AS) is associated with an increase in cardiovascular (CV) morbidity when compared to the general population. The increased risk of CV involvement in AS is likely multifactorial including inflammation accelerating atherosclerosis and the cardiac inflammation itself in the form of aortitis and conduction anomalies. Establishing indisputable evidence linking AS and CV disease is challenging due to AS being relatively rare and it affects 1:1,000 and all studies analyzing the association between AS and CV disease involve a small sample size making long-term outcome measurements limited. The article reviews the literature studying the association between AS and CV disease as well as the impact of therapies for AS on the CV system (CVS).
与普通人群相比，强直性脊柱炎（AS）与心血管（CV）发病率的增加有关。AS患者发生心血管病变的风险增加可能是多因素导致的，包括炎症加速动脉粥样硬化以及以主动脉炎和传导异常形式出现的心脏炎症本身。由于AS相对罕见，发病率为千分之一，且所有分析AS与心血管疾病之间关联的研究样本量较小，使得长期结果测量受限，因此要建立AS与心血管疾病之间无可争议的证据具有挑战性。本文回顾了研究AS与心血管疾病之间关联的文献，以及AS治疗对心血管系统（CVS）的影响。
