Banu Rekha V V, Ramachandran Rajeswari, Kuppu Rao K V, Rahman Fathima, Adhilakshmi A R, Kalaiselvi D, Murugesan P, Sundaram V, Narayanan P R
Tuberculosis Research Centre, Chennai.
Indian J Tuberc. 2009 Jul;56(3):132-40.
Long term status of pulmonary tuberculosis (PTB) patients treated with short course chemotherapy (SCC) regimens remains unknown.
To assess the clinical, bacteriological, radiological status and health related quality of life (HRQoL) of PTB patients 14-18 years after successful treatment with SCC.
In a cross-sectional study, cured PTB patients treated during 1986-1990 at the Tuberculosis Research Centre (TRC) were investigated for their current health status including pulmonary function tests (PFT). The St Georges respiratory questionnaire (SGRQ) was used to assess the HRQoL.
The mean period after treatment completion for the 363 eligible participants was 16.5 yrs (range 14-18 yrs., 84% coverage); 25 (7%) had been re-treated and 52 (14%) died. Among the investigated, 58 (29%) had persistent respiratory symptoms; 170 (86%) had radiological sequelae but none had active disease. Abnormal PFT was observed in 96 (65%) with predominantly restrictive type of disease in 66 (45%). The SGRQ scores for activity and impact were high implying impairment in HRQoL.
Assessment of long term status of cured PTB patients showed an impairment of lung functions and HRQoL highlighting the need to address these issues in the management of TB that may provide added value to patient care.
采用短程化疗（SCC）方案治疗的肺结核（PTB）患者的长期状况尚不清楚。
评估PTB患者在成功接受SCC治疗14 - 18年后的临床、细菌学、放射学状况以及健康相关生活质量（HRQoL）。
在一项横断面研究中，对1986 - 1990年期间在结核病研究中心（TRC）接受治疗的已治愈PTB患者的当前健康状况进行调查，包括肺功能测试（PFT）。采用圣乔治呼吸问卷（SGRQ）评估HRQoL。
363名符合条件的参与者治疗结束后的平均时间为16.5年（范围14 - 18年，覆盖率84%）；25人（7%）接受了再次治疗，52人（14%）死亡。在被调查者中，58人（29%）有持续的呼吸道症状；170人（86%）有放射学后遗症，但均无活动性疾病。96人（65%）观察到肺功能测试异常，其中66人（45%）主要为限制性疾病类型。活动和影响方面的SGRQ评分较高，这意味着HRQoL受损。
对已治愈PTB患者的长期状况评估显示肺功能和HRQoL受损，这突出表明在结核病管理中需要解决这些问题，这可能会为患者护理增添价值。
