Department of Periodontology, County Hospital of Gävle-Sandviken, 801 87 Gävle, Sweden.
J Periodontol. 2010 Jun;81(6):870-6. doi: 10.1902/jop.2010.090680.
That oral health is related to the development of different cardiovascular disorders is reported in a number of studies. This study investigates if different parameters of oral health are associated with future mortality in different cardiovascular disorders in a dose-dependent manner.
A total of 7,674 subjects (3,300 males and 4,374 females; age range 20 to 89 years) received a dental examination by specialists in periodontology between the years 1976 and 2002. Number of remaining teeth, severity of periodontal disease, number of deepened periodontal pockets, and bleeding on probing were evaluated in relation to cause of death.
During a median follow-up period of 12 years, 629 of the subjects died. For 299 subjects the cause of mortality was cardiovascular disease (CVD); 167 of these subjects died from coronary heart disease (CHD); 83 died from stroke; and 49 died from aortic aneurysm or congestive heart failure. The causes of death for the remaining 330 subjects were other than CVD. After adjustment for age, gender, and smoking, number of remaining teeth predicted in a dose-dependent manner all-cause mortality and mortality in CVD and in CHD (P <0.0001 for all), but not mortality from stroke (P = 0.15). Cox regression analysis revealed a seven-fold increased risk for mortality from CHD in subjects with <10 teeth compared to those with >25 teeth. Severity of periodontal disease, number of deepened periodontal pockets, and bleeding on probing were not related to mortality in a dose-dependent manner after adjustment for confounders.
This fairly large, prospective study with a long follow-up period presents for the first time a dose-dependent relationship between number of teeth and both all-cause and CVD mortality, indicating a link between oral health and CVD, and that the number of teeth is a proper indicator for oral health in this respect.
多项研究报告称，口腔健康与多种心血管疾病的发生有关。本研究旨在调查口腔健康的不同参数是否与不同心血管疾病的未来死亡率存在剂量依赖性关系。
共有 7674 名受试者（3300 名男性和 4374 名女性；年龄 20 至 89 岁）于 1976 年至 2002 年间由牙周病专家进行了口腔检查。评估了剩余牙齿数量、牙周病严重程度、牙周袋深度、探诊出血与死亡原因的关系。
在中位随访 12 年期间，629 名受试者死亡。299 名受试者的死亡原因为心血管疾病（CVD）；其中 167 名死于冠心病（CHD）；83 名死于中风；49 名死于主动脉瘤或充血性心力衰竭。其余 330 名受试者的死亡原因为非 CVD。在校正年龄、性别和吸烟因素后，剩余牙齿数量与全因死亡率以及 CVD 和 CHD 死亡率呈剂量依赖性相关（所有 P 值均<0.0001），但与中风死亡率无关（P=0.15）。Cox 回归分析显示，与剩余牙齿数量>25 颗的受试者相比，牙齿数量<10 颗的受试者死于 CHD 的风险增加了 7 倍。在校正混杂因素后，牙周病严重程度、牙周袋深度和探诊出血与死亡率之间不存在剂量依赖性关系。
这项随访时间较长的大型前瞻性研究首次提出了牙齿数量与全因死亡率和 CVD 死亡率之间存在剂量依赖性关系，表明口腔健康与 CVD 之间存在关联，且牙齿数量是反映口腔健康的一个恰当指标。
